Seroatlas · Human Serome Atlas

CDH20

Cadherin-20

Also known as: CAD20_HUMAN, Cdh7, CDH7L3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBT6
Gene: CDH20
Ensembl: ENSG00000101542
Chromosome: 18
Canonical length: 801 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

801 residues, UniProt reviewed canonical sequence.

>Q9HBT6|CDH20
     1  MWTSGRMSNA KNWLGLGMSL YFWGLMDLTT TVLSDTPTPQ GELEALLSDK PQSHQRTKRS
    61  WVWNQFFVLE EYTGTDPLYV GKLHSDMDRG DGSIKYILSG EGAGIVFTID DTTGDIHAIQ
   121  RLDREERAQY TLRAQALDRR TGRPMEPESE FIIKIQDIND NEPKFLDGPY VATVPEMSPV
   181  GTSVIQVTAT DADDPTYGNS ARVVYSILQG QPYFSVDSKT GVIRTALMNM DREAKEYYEV
   241  IIQAKDMGGQ LGGLAGTTTV NITLSDVNDN PPRFPQKHYQ MSVLESAPIS STVGRVFAKD
   301  LDEGINAEMK YTIVDGDGAD AFDISTDPNF QVGIITVKKP LSFESKKSYT LKVEGANPHL
   361  EMRFLNLGPF QDTTTVHISV EDVDEPPVFE PGFYFVEVPE DVAIGTTIQI ISAKDPDVTN
   421  NSIRYSIDRS SDPGRFFYVD ITTGALMTAR PLDREEFSWH NITVLAMEMN NPSQVGSVPV
   481  TIKVLDVNDN APEFPRFYEA FVCENAKAGQ LIQTVSAVDQ DDPRNGQHFY YSLAPEAANN
   541  PNFTIRDNQD NTARILTRRS GFRQQEQSVF HLPILIADSG QPVLSSTGTL TIQVCSCDDD
   601  GHVMSCSPEA YMLPVSLSRG ALIAILACIF VLLVLVLLIL SMRRHRKQPY IIDDEENIHE
   661  NIVRYDDEGG GEEDTEAFDI AAMWNPREAQ AGAAPKTRQD MLPEIESLSR YVPQTCAVNS
   721  TVHSYVLAKL YEADMDLWAP PFDSLQTYMF EGDGSVAGSL SSLQSATSDS EQSFDFLTDW
   781  GPRFRKLAEL YGASEGPAPL W

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDH20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

tongue: 22 nTPM
basal ganglia: 17 nTPM
amygdala: 17 nTPM
midbrain: 16 nTPM
cerebral cortex: 15 nTPM
spinal cord: 15 nTPM

Single-cell type

bergmann glia: 2,110 nCPM
astrocytes: 2,068 nCPM
thymic myoid cells: 1,652 nCPM
retinal bipolar cells: 1,299 nCPM
oligodendrocytes: 1,120 nCPM
oligodendrocyte progenitor cells: 1,064 nCPM

Immune cell

basophil: 2.3 nTPM
neutrophil: 0.1 nTPM
total PBMC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 71 nTPM
basal ganglia: 65 nTPM
medulla oblongata: 64 nTPM
midbrain: 63 nTPM
cerebellum: 55 nTPM
thalamus: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.46
gnomAD missense Z: 1.38
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDH20 as an antibody target. Whether an autoantibody or antibody against CDH20 could matter depends on whether native CDH20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDH20 is annotated at the cell surface, where native CDH20 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDH20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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