Seroatlas · Human Serome Atlas

CDH2

Cadherin-2

Also known as: CADH2_HUMAN, CD325, CDHN, NCAD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P19022
Gene
CDH2
Ensembl
ENSG00000170558
Chromosome
18
Canonical length
906 aa
Protein class
CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Cell Junctions
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

906 residues, UniProt reviewed canonical sequence.

>P19022|CDH2
     1  MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH EGQPLLNVKF
    61  SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA KFLIYAQDKE TQEKWQVAVK
   121  LSLKPTLTEE SVKESAEVEE IVFPRQFSKH SGHLQRQKRD WVIPPINLPE NSRGPFPQEL
   181  VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV
   241  DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL
   301  NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY
   361  GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV ANLTVTDKDQ PHTPAWNAVY
   421  RISGGDPTGR FAIQTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS
   481  TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP
   541  ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND
   601  NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD
   661  FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL
   721  GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE
   781  EDQDYDLSQL QQPDTVEPDA IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL
   841  KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM
   901  YGGGDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
184 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 184 nTPM
  • adrenal gland: 63 nTPM
  • retina: 56 nTPM
  • liver: 54 nTPM
  • testis: 42 nTPM
  • cerebral cortex: 33 nTPM

Single-cell type

  • cardiomyocytes: 1,145 nCPM
  • adrenal cortex cells: 850 nCPM
  • sertoli cells: 734 nCPM
  • cone photoreceptor cells: 714 nCPM
  • pituitary stem cells: 548 nCPM
  • rod photoreceptor cells: 511 nCPM

Immune cell

  • basophil: 1.7 nTPM
  • neutrophil: 1.3 nTPM
  • MAIT T-cell: 0.3 nTPM
  • NK-cell: 0.3 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • hypothalamus: 72 nTPM
  • cerebral cortex: 65 nTPM
  • thalamus: 64 nTPM
  • basal ganglia: 63 nTPM
  • midbrain: 60 nTPM
  • hippocampal formation: 59 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDH2.

Disease | AllUniProt

Conditions CDH2 is implicated in, by any mechanism.

  • Arrhythmogenic right ventricular dysplasia, familial, 14 (ARVD14) MIM:618920
  • Agenesis of corpus callosum, cardiac, ocular, and genital syndrome (ACOGS) MIM:618929
  • Attention deficit-hyperactivity disorder 8 (ADHD8) MIM:619957

Disease | GeneticClinVar

24 pathogenic / likely-pathogenic of 1,156 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
2.09
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDH2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDH2 as an antibody target. Whether an autoantibody or antibody against CDH2 could matter depends on whether native CDH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDH2 is annotated at the cell surface, where native CDH2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDH2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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