Seroatlas · Human Serome Atlas

CDH24

Cadherin-24

Also known as: CAD24_HUMAN, CDH11L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UP0
Gene: CDH24
Ensembl: ENSG00000139880
Chromosome: 14
Canonical length: 819 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Enables several functions, including alpha-catenin binding activity; beta-catenin binding activity; and delta-catenin binding activity. Acts upstream of or within cell-cell adhesion. Located in cell-cell junction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

819 residues, UniProt reviewed canonical sequence.

>Q86UP0|CDH24
     1  MWGLVRLLLA WLGGWGCMGR LAAPARAWAG SREHPGPALL RTRRSWVWNQ FFVIEEYAGP
    61  EPVLIGKLHS DVDRGEGRTK YLLTGEGAGT VFVIDEATGN IHVTKSLDRE EKAQYVLLAQ
   121  AVDRASNRPL EPPSEFIIKV QDINDNPPIF PLGPYHATVP EMSNVGTSVI QVTAHDADDP
   181  SYGNSAKLVY TVLDGLPFFS VDPQTGVVRT AIPNMDRETQ EEFLVVIQAK DMGGHMGGLS
   241  GSTTVTVTLS DVNDNPPKFP QSLYQFSVVE TAGPGTLVGR LRAQDPDLGD NALMAYSILD
   301  GEGSEAFSIS TDLQGRDGLL TVRKPLDFES QRSYSFRVEA TNTLIDPAYL RRGPFKDVAS
   361  VRVAVQDAPE PPAFTQAAYH LTVPENKAPG TLVGQISAAD LDSPASPIRY SILPHSDPER
   421  CFSIQPEEGT IHTAAPLDRE ARAWHNLTVL ATELGWSWGP ERGWVPLLVA EWSAPAAPPQ
   481  RSPVGSAVGI PQDSSAQASR VQVAIQTLDE NDNAPQLAEP YDTFVCDSAA PGQLIQVIRA
   541  LDRDEVGNSS HVSFQGPLGP DANFTVQDNR DGSASLLLPS RPAPPRHAPY LVPIELWDWG
   601  QPALSSTATV TVSVCRCQPD GSVASCWPEA HLSAAGLSTG ALLAIITCVG ALLALVVLFV
   661  ALRRQKQEAL MVLEEEDVRE NIITYDDEGG GEEDTEAFDI TALQNPDGAA PPAPGPPARR
   721  DVLPRARVSR QPRPPGPADV AQLLALRLRE ADEDPGVPPY DSVQVYGYEG RGSSCGSLSS
   781  LGSGSEAGGA PGPAEPLDDW GPLFRTLAEL YGAKEPPAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDH24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 7.8 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 7.8 nTPM
endometrium: 7.5 nTPM
cervix: 5.3 nTPM
fallopian tube: 4.7 nTPM
thyroid gland: 4.4 nTPM
adipose tissue: 4.1 nTPM

Single-cell type

retinal amacrine cells: 48 nCPM
astrocytes: 14 nCPM
bergmann glia: 13 nCPM
vascular endothelial cells: 12 nCPM
tuft cells: 12 nCPM
adrenal medulla cells: 11 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 21 nTPM
white matter: 13 nTPM
basal ganglia: 12 nTPM
hypothalamus: 11 nTPM
medulla oblongata: 11 nTPM
midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 1.39
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDH24 as an antibody target. Whether an autoantibody or antibody against CDH24 could matter depends on whether native CDH24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDH24 is annotated at the cell surface, where native CDH24 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDH24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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