Yippee/Mis18/Cereblon

Definition

This domain is found in both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins PMID:11240639. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A [[cite:PMID:17199038], [cite:PMID:22264723]]. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus PMID:22552327. This domain includes the CULT domain from proteins such as Cereblon PMID:25569776. Pro-Apoptotic protein MOH1 from S.cerevisiae is involved in mitochondria-dependent apoptosis induced by DNA damage PMID:28173693.

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• CRBN
• MIS18A
• OIP5
• YPEL1
• YPEL2
• YPEL3
• YPEL4
• YPEL5