Seroatlas · Human Serome Atlas

YPEL1

Protein yippee-like 1

Also known as: YPEL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60688
Gene
YPEL1
Ensembl
ENSG00000100027
Chromosome
22
Canonical length
119 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene is located in the region associated with DiGeorge syndrome on chromosome 22. The encoded protein localizes to the centrosome and nucleolus and may play a role in the regulation of cell division. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>O60688|YPEL1
     1  MVKMTKSKTF QAYLPNCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL FNSVVNVGCG
    61  PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY KEGKFIIELA HMIKDNGWE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YPEL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
150 nTPM

Expression across tissuesHPA

Tissue

  • testis: 150 nTPM
  • basal ganglia: 28 nTPM
  • skeletal muscle: 24 nTPM
  • cerebral cortex: 14 nTPM
  • thymus: 14 nTPM
  • amygdala: 12 nTPM

Single-cell type

  • late spermatids: 1,955 nCPM
  • late primary spermatocytes: 1,129 nCPM
  • early spermatids: 646 nCPM
  • nk-cells: 135 nCPM
  • early primary spermatocytes: 102 nCPM
  • choroid plexus epithelial cells: 102 nCPM

Immune cell

  • NK-cell: 2.4 nTPM
  • gdT-cell: 1.9 nTPM
  • memory CD8 T-cell: 1.8 nTPM
  • plasmacytoid DC: 1.7 nTPM
  • MAIT T-cell: 1.5 nTPM
  • naive CD8 T-cell: 0.9 nTPM

Brain region

  • basal ganglia: 63 nTPM
  • cerebral cortex: 37 nTPM
  • hypothalamus: 31 nTPM
  • amygdala: 26 nTPM
  • hippocampal formation: 25 nTPM
  • white matter: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.61
gnomAD missense Z
2.02
DepMap mean gene effect
-0.32
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YPEL1 as an antibody target. Whether an autoantibody or antibody against YPEL1 could matter depends on whether native YPEL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YPEL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YPEL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/YPEL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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