Seroatlas · Human Serome Atlas

OIP5

Protein Mis18-beta

Also known as: CT86, hMIS18beta, MIS18B, MS18B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43482
Gene: OIP5
Ensembl: ENSG00000104147
Chromosome: 15
Canonical length: 229 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>O43482|OIP5
     1  MAAQPLRHRS RCATPPRGDF CGGTERAIDQ ASFTTSMEWD TQVVKGSSPL GPAGLGAEEP
    61  AAGPQLPSWL QPERCAVFQC AQCHAVLADS VHLAWDLSRS LGAVVFSRVT NNVVLEAPFL
   121  VGIEGSLKGS TYNLLFCGSC GIPVGFHLYS THAALAALRG HFCLSSDKMV CYLLKTKAIV
   181  NASEMDIQNV PLSEKIAELK EKIVLTHNRL KSLMKILSEV TPDQSKPEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OIP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

testis: 20 nTPM
bone marrow: 9.7 nTPM
skeletal muscle: 9.6 nTPM
thymus: 8.4 nTPM
lymph node: 5.4 nTPM
tonsil: 4.9 nTPM

Single-cell type

late primary spermatocytes: 133 nCPM
myonuclei: 131 nCPM
early primary spermatocytes: 108 nCPM
oocytes: 101 nCPM
differentiating spermatogonia: 92 nCPM
cardiomyocytes: 59 nCPM

Immune cell

plasmacytoid DC: 4.1 nTPM
T-reg: 3.1 nTPM
naive CD4 T-cell: 1.3 nTPM
naive B-cell: 1.2 nTPM
NK-cell: 1.2 nTPM
memory B-cell: 1 nTPM

Brain region

cerebellum: 3.5 nTPM
white matter: 2.1 nTPM
midbrain: 2 nTPM
pons: 1.9 nTPM
cerebral cortex: 1.8 nTPM
medulla oblongata: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: -1.31
DepMap mean gene effect: -0.99
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OIP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OIP5 as an antibody target. Whether an autoantibody or antibody against OIP5 could matter depends on whether native OIP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OIP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OIP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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