YPEL3
Protein yippee-like 3
Also known as: MGC10500, YPEL3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P61236
- Gene
- YPEL3
- Ensembl
- ENSG00000090238
- Chromosome
- 16
- Canonical length
- 119 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable metal ion binding activity. Involved in positive regulation of cellular senescence. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
119 residues, UniProt reviewed canonical sequence.
>P61236|YPEL3
1 MVRISKPKTF QAYLDDCHRR YSCAHCRAHL ANHDDLISKS FQGSQGRAYL FNSVVNVGCG
61 PAEERVLLTG LHAVADIHCE NCKTTLGWKY EQAFESSQKY KEGKYIIELN HMIKDNGWDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against YPEL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 276 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 276 nTPM
- cerebral cortex: 257 nTPM
- amygdala: 201 nTPM
- skeletal muscle: 184 nTPM
- hippocampal formation: 175 nTPM
- spleen: 169 nTPM
Single-cell type
- neutrophils: 1,045 nCPM
- esophageal apical cells: 358 nCPM
- erythrocytes: 225 nCPM
- platelets: 213 nCPM
- cytotrophoblasts: 201 nCPM
- prostatic club cells: 196 nCPM
Immune cell
- neutrophil: 48 nTPM
- eosinophil: 31 nTPM
- basophil: 23 nTPM
- NK-cell: 5.8 nTPM
- memory CD4 T-cell: 4.4 nTPM
- naive CD4 T-cell: 4.1 nTPM
Brain region
- cerebral cortex: 281 nTPM
- white matter: 243 nTPM
- pons: 213 nTPM
- cerebellum: 200 nTPM
- basal ganglia: 196 nTPM
- amygdala: 193 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about YPEL3.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 17 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- YPEL3-related condition
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.15
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 1.54
- DepMap mean gene effect
- -0.23
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads YPEL3 as an antibody target. Whether an autoantibody or antibody against YPEL3 could matter depends on whether native YPEL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
YPEL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label YPEL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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