Seroatlas · Human Serome Atlas

YPEL2

Protein yippee-like 2

Also known as: FKSG4, YPEL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96QA6
Gene
YPEL2
Ensembl
ENSG00000175155
Chromosome
17
Canonical length
119 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable metal ion binding activity. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>Q96QA6|YPEL2
     1  MVKMTRSKTF QAYLPSCHRT YSCIHCRAHL ANHDELISKS FQGSQGRAYL FNSVVNVGCG
    61  PAEERVLLTG LHAVADIYCE NCKTTLGWKY EHAFESSQKY KEGKYIIELA HMIKDNGWD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YPEL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
77 nTPM

Expression across tissuesHPA

Tissue

  • retina: 77 nTPM
  • skeletal muscle: 29 nTPM
  • bone marrow: 27 nTPM
  • blood vessel: 23 nTPM
  • heart muscle: 23 nTPM
  • tongue: 21 nTPM

Single-cell type

  • rod photoreceptor cells: 744 nCPM
  • retinal horizontal cells: 517 nCPM
  • oligodendrocytes: 315 nCPM
  • myonuclei: 270 nCPM
  • proximal tubule cells: 225 nCPM
  • corticotrophs: 171 nCPM

Immune cell

  • non-classical monocyte: 18 nTPM
  • intermediate monocyte: 17 nTPM
  • basophil: 14 nTPM
  • NK-cell: 13 nTPM
  • classical monocyte: 13 nTPM
  • neutrophil: 11 nTPM

Brain region

  • white matter: 66 nTPM
  • cerebral cortex: 41 nTPM
  • basal ganglia: 41 nTPM
  • medulla oblongata: 40 nTPM
  • pons: 37 nTPM
  • hypothalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.95
gnomAD missense Z
1.8
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YPEL2 as an antibody target. Whether an autoantibody or antibody against YPEL2 could matter depends on whether native YPEL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YPEL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YPEL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/YPEL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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