Seroatlas · Human Serome Atlas

YPEL4

Protein yippee-like 4

Also known as: FLJ30213, YPEL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NS1
Gene: YPEL4
Ensembl: ENSG00000166793
Chromosome: 11
Canonical length: 127 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable metal ion binding activity. Predicted to act upstream of or within several processes, including negative regulation of erythrocyte clearance; negative regulation of erythrocyte differentiation; and protein localization to plasma membrane. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>Q96NS1|YPEL4
     1  MPSCDPGPGP ACLPTKTFRS YLPRCHRTYS CVHCRAHLAK HDELISKSFQ GSHGRAYLFN
    61  SVVNVGCGPA EQRLLLTGLH SVADIFCESC KTTLGWKYEQ AFETSQKYKE GKYIIEMSHM
   121  VKDNGWD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YPEL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 39 nTPM
cerebral cortex: 32 nTPM
amygdala: 18 nTPM
hypothalamus: 16 nTPM
hippocampal formation: 15 nTPM
basal ganglia: 11 nTPM

Single-cell type

early spermatids: 42 nCPM
erythrocytes: 37 nCPM
retinal amacrine cells: 21 nCPM
retinal bipolar cells: 20 nCPM
late spermatids: 20 nCPM
brain excitatory neurons: 19 nCPM

Immune cell

MAIT T-cell: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 46 nTPM
white matter: 38 nTPM
cerebellum: 28 nTPM
pons: 27 nTPM
basal ganglia: 26 nTPM
hypothalamus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0.2
gnomAD missense Z: 1.33
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YPEL4 as an antibody target. Whether an autoantibody or antibody against YPEL4 could matter depends on whether native YPEL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YPEL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YPEL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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