TMPRSS11A
Transmembrane protease serine 11A
Also known as: ECRG1, HATL1, HESP, TM11A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZMR5
- Gene
- TMPRSS11A
- Ensembl
- ENSG00000187054
- Chromosome
- 4
- Canonical length
- 418 aa
- Protein class
- Enzymes, Predicted membrane proteins, Transporters
OverviewNCBI Gene
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
418 residues, UniProt reviewed canonical sequence.
>Q6ZMR5|TMPRSS11A
1 MMYRTVGFGT RSRNLKPWMI AVLIVLSLTV VAVTIGLLVH FLVFDQKKEY YHGSFKILDP
61 QINNNFGQSN TYQLKDLRET TENLVDEIFI DSAWKKNYIK NQVVRLTPEE DGVKVDVIMV
121 FQFPSTEQRA VREKKIQSIL NQKIRNLRAL PINASSVQVN AMSSSTGELT VQASCGKRVV
181 PLNVNRIASG VIAPKAAWPW QASLQYDNIH QCGATLISNT WLVTAAHCFQ KYKNPHQWTV
241 SFGTKINPPL MKRNVRRFII HEKYRSAARE YDIAVVQVSS RVTFSDDIRQ ICLPEASASF
301 QPNLTVHITG FGALYYGGES QNDLREARVK IISDDVCKQP QVYGNDIKPG MFCAGYMEGI
361 YDACRGDSGG PLVTRDLKDT WYLIGIVSWG DNCGQKDKPG VYTQVTYYRN WIASKTGILocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMPRSS11A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 81 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 81 nTPM
- vagina: 39 nTPM
- cervix: 34 nTPM
- tonsil: 27 nTPM
- salivary gland: 11 nTPM
- retina: 0.4 nTPM
Single-cell type
- esophageal apical cells: 1,411 nCPM
- esophageal suprabasal cells: 282 nCPM
- suprabasal keratinocytes: 65 nCPM
- esophageal basal cells: 51 nCPM
- retinal ganglion cells: 39 nCPM
- epicardial cells: 34 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 4.9 nTPM
- pons: 4.2 nTPM
- medulla oblongata: 3.8 nTPM
- white matter: 3.5 nTPM
- midbrain: 3.1 nTPM
- basal ganglia: 2.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.29
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.5
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TMPRSS11A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMPRSS11A as an antibody target. Whether an autoantibody or antibody against TMPRSS11A could matter depends on whether native TMPRSS11A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMPRSS11A is annotated at the cell surface, where native TMPRSS11A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TMPRSS11A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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