YES1
Tyrosine-protein kinase Yes
Also known as: c-yes, HsT441, Yes, YES_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P07947
- Gene
- YES1
- Ensembl
- ENSG00000176105
- Chromosome
- 18
- Canonical length
- 543 aa
- Protein class
- Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Plasma membrane,Cytosol
OverviewNCBI Gene
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
543 residues, UniProt reviewed canonical sequence.
>P07947|YES1
1 MGCIKSKENK SPAIKYRPEN TPEPVSTSVS HYGAEPTTVS PCPSSSAKGT AVNFSSLSMT
61 PFGGSSGVTP FGGASSSFSV VPSSYPAGLT GGVTIFVALY DYEARTTEDL SFKKGERFQI
121 INNTEGDWWE ARSIATGKNG YIPSNYVAPA DSIQAEEWYF GKMGRKDAER LLLNPGNQRG
181 IFLVRESETT KGAYSLSIRD WDEIRGDNVK HYKIRKLDNG GYYITTRAQF DTLQKLVKHY
241 TEHADGLCHK LTTVCPTVKP QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT
301 KVAIKTLKPG TMMPEAFLQE AQIMKKLRHD KLVPLYAVVS EEPIYIVTEF MSKGSLLDFL
361 KEGDGKYLKL PQLVDMAAQI ADGMAYIERM NYIHRDLRAA NILVGENLVC KIADFGLARL
421 IEDNEYTARQ GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LQTELVTKGR VPYPGMVNRE
481 VLEQVERGYR MPCPQGCPES LHELMNLCWK KDPDERPTFE YIQSFLEDYF TATEPQYQPG
541 ENLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against YES1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 47 nTPM
Expression across tissuesHPA
Tissue
- liver: 47 nTPM
- placenta: 39 nTPM
- kidney: 26 nTPM
- spleen: 26 nTPM
- pancreas: 25 nTPM
- adipose tissue: 24 nTPM
Single-cell type
- nk-cells: 529 nCPM
- lymphatic endothelial cells: 307 nCPM
- vascular endothelial cells: 222 nCPM
- sertoli cells: 218 nCPM
- salivary basal cells: 218 nCPM
- salivary myoepithelial cells: 195 nCPM
Immune cell
- basophil: 20 nTPM
- gdT-cell: 2.2 nTPM
- naive CD8 T-cell: 1.7 nTPM
- MAIT T-cell: 1.5 nTPM
- memory CD8 T-cell: 1.2 nTPM
- NK-cell: 1.1 nTPM
Brain region
- thalamus: 22 nTPM
- spinal cord: 21 nTPM
- medulla oblongata: 21 nTPM
- hypothalamus: 20 nTPM
- white matter: 20 nTPM
- midbrain: 19 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.65
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.16
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell differentiation
- cell surface receptor protein tyrosine kinase signaling pathway
- cellular response to platelet-derived growth factor stimulus
- cellular response to retinoic acid
- cellular response to transforming growth factor beta stimulus
- ephrin receptor signaling pathway
- Fc-gamma receptor signaling pathway involved in phagocytosis
- leukocyte migration
- negative regulation of inflammatory response to antigenic stimulus
- positive regulation of transcription by RNA polymerase II
- protein modification process
- regulation of D-glucose transmembrane transport
- regulation of vascular permeability
- T cell costimulation
Molecular functions
- ATP binding
- enzyme binding
- non-membrane spanning protein tyrosine kinase activity
- phosphotyrosine residue binding
- protein tyrosine kinase activity
- signaling receptor binding
- transmembrane transporter binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protein kinase domain
- SH2 domain
- Serine-threonine/tyrosine-protein kinase, catalytic domain
- SH3 domain
- Tyrosine-protein kinase, active site
- Protein kinase-like domain superfamily
- Protein kinase, ATP binding site
- Tyrosine-protein kinase, catalytic domain
- SH3-like domain superfamily
- SH2 domain superfamily
- Non-receptor tyrosine kinases involved in cell signaling
- SH2 domain
- SH3 domain
- Protein tyrosine and serine/threonine kinase
- Tyrosine-protein kinase Yes, SH3 domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of YES1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads YES1 as an antibody target. Whether an autoantibody or antibody against YES1 could matter depends on whether native YES1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
YES1 is annotated at the cell surface, where native YES1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label YES1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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