Seroatlas · Human Serome Atlas

OLIG1

Oligodendrocyte transcription factor 1

Also known as: BHLHB6, bHLHe21, OLIG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TAK6
Gene
OLIG1
Ensembl
ENSG00000184221
Chromosome
21
Canonical length
271 aa
Protein class
Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Predicted to be involved in axon development; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within neuron fate commitment. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q8TAK6|OLIG1
     1  MYYAVSQARV NAVPGTMLRP QRPGDLQLGA SLYELVGYRQ PPSSSSSSTS STSSTSSSST
    61  TAPLLPKAAR EKPEAPAEPP GPGPGSGAHP GGSARPDAKE EQQQQLRRKI NSRERKRMQD
   121  LNLAMDALRE VILPYSAAHC QGAPGRKLSK IATLLLARNY ILLLGSSLQE LRRALGEGAG
   181  PAAPRLLLAG LPLLAAAPGS VLLAPGAVGP PDALRPAKYL SLALDEPPCG QFALPGGGAG
   241  GPGLCTCAVC KFPHLVPASL GLAAVQAQFS K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLIG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
228 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 228 nTPM
  • hippocampal formation: 225 nTPM
  • midbrain: 221 nTPM
  • spinal cord: 203 nTPM
  • hypothalamus: 163 nTPM
  • basal ganglia: 162 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 701 nCPM
  • oligodendrocytes: 248 nCPM
  • epididymal principal cells: 19 nCPM
  • astrocytes: 19 nCPM
  • epididymal efferent duct absorptive cells: 14 nCPM
  • monocytes: 9 nCPM

Immune cell

  • eosinophil: 38 nTPM
  • basophil: 12 nTPM
  • non-classical monocyte: 2.5 nTPM
  • classical monocyte: 2.4 nTPM
  • intermediate monocyte: 0.9 nTPM
  • total PBMC: 0.6 nTPM

Brain region

  • white matter: 311 nTPM
  • basal ganglia: 292 nTPM
  • midbrain: 270 nTPM
  • medulla oblongata: 270 nTPM
  • thalamus: 243 nTPM
  • cerebral cortex: 226 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0.66
gnomAD missense Z
1.42
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OLIG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OLIG1 as an antibody target. Whether an autoantibody or antibody against OLIG1 could matter depends on whether native OLIG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OLIG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OLIG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OLIG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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