Seroatlas · Human Serome Atlas

NEIL1

Endonuclease 8-like 1

Also known as: FLJ22402, FPG1, hFPG1, NEI1, NEIL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96FI4
Gene: NEIL1
Ensembl: ENSG00000140398
Chromosome: 15
Canonical length: 390 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

390 residues, UniProt reviewed canonical sequence.

>Q96FI4|NEIL1
     1  MPEGPELHLA SQFVNEACRA LVFGGCVEKS SVSRNPEVPF ESSAYRISAS ARGKELRLIL
    61  SPLPGAQPQQ EPLALVFRFG MSGSFQLVPR EELPRHAHLR FYTAPPGPRL ALCFVDIRRF
   121  GRWDLGGKWQ PGRGPCVLQE YQQFRENVLR NLADKAFDRP ICEALLDQRF FNGIGNYLRA
   181  EILYRLKIPP FEKARSVLEA LQQHRPSPEL TLSQKIRTKL QNPDLLELCH SVPKEVVQLG
   241  GKGYGSESGE EDFAAFRAWL RCYGMPGMSS LQDRHGRTIW FQGDPGPLAP KGRKSRKKKS
   301  KATQLSPEDR VEDALPPSKA PSRTRRAKRD LPKRTATQRP EGTSLQQDPE APTVPKKGRR
   361  KGRQAASGHC RPRKVKADIP SLEPEGTSAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEIL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 26 nTPM
salivary gland: 15 nTPM
adrenal gland: 14 nTPM
ovary: 13 nTPM
cervix: 13 nTPM
fallopian tube: 12 nTPM

Single-cell type

epicardial cells: 150 nCPM
cardiomyocytes: 119 nCPM
adrenal cortex cells: 72 nCPM
respiratory ciliated cells: 62 nCPM
breast lactating cells: 56 nCPM
lacrimal acinar cells: 43 nCPM

Immune cell

NK-cell: 16 nTPM
naive B-cell: 6.7 nTPM
gdT-cell: 5.3 nTPM
memory B-cell: 4.9 nTPM
naive CD4 T-cell: 1.5 nTPM
naive CD8 T-cell: 1.5 nTPM

Brain region

cerebellum: 25 nTPM
cerebral cortex: 22 nTPM
white matter: 16 nTPM
basal ganglia: 16 nTPM
choroid plexus: 15 nTPM
hypothalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: -0.26
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

base-excision repair
base-excision repair, gap-filling
depyrimidination
response to oxidative stress
negative regulation of nuclease activity

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small ribosomal subunit protein uS13-like, H2TH
Formamidopyrimidine-DNA glycosylase, catalytic domain
Formamidopyrimidine-DNA glycosylase, H2TH DNA-binding
Formamidopyrimidine-DNA glycosylase, N-terminal
Endonuclease VIII-like 1, DNA binding
Formamidopyrimidine-DNA glycosylase N-terminal domain
Endonuclease VIII-like 1, DNA bind

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NEIL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEIL1 as an antibody target. Whether an autoantibody or antibody against NEIL1 could matter depends on whether native NEIL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEIL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEIL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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