Seroatlas · Human Serome Atlas

POLD4

DNA polymerase delta subunit 4

Also known as: DPOD4_HUMAN, p12, POLDS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCU8
Gene: POLD4
Ensembl: ENSG00000175482
Chromosome: 11
Canonical length: 107 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Centriolar satellite

OverviewNCBI Gene

This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>Q9HCU8|POLD4
     1  MGRKRLITDS YPVVKRREGP AGHSKGELAP ELGEEPQPRD EEEAELELLR QFDLAWQYGP
    61  CTGITRLQRW CRAKQMGLEP PPEVWQVLKT HPGDPRFQCS LWHLYPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 198 nTPM

Expression across tissuesHPA

Tissue

liver: 198 nTPM
blood vessel: 92 nTPM
small intestine: 88 nTPM
esophagus: 87 nTPM
duodenum: 81 nTPM
colon: 80 nTPM

Single-cell type

colonocytes: 386 nCPM
enterocytes: 360 nCPM
goblet cells: 217 nCPM
foveolar cells: 195 nCPM
enteric transient amplifying cells: 105 nCPM
esophageal apical cells: 93 nCPM

Immune cell

non-classical monocyte: 379 nTPM
naive B-cell: 357 nTPM
memory B-cell: 335 nTPM
eosinophil: 259 nTPM
intermediate monocyte: 193 nTPM
classical monocyte: 148 nTPM

Brain region

medulla oblongata: 29 nTPM
thalamus: 28 nTPM
pons: 27 nTPM
midbrain: 27 nTPM
cerebral cortex: 26 nTPM
white matter: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0.15
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

DNA polymerase delta, subunit 4
DNA polymerase delta, subunit 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLD4 as an antibody target. Whether an autoantibody or antibody against POLD4 could matter depends on whether native POLD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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