MAP2K7

Protein identityUniProt · HPA

UniProt accession

O14733

Gene

MAP2K7

Ensembl

ENSG00000076984

Chromosome

19

Canonical length

419 aa

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>O14733|MAP2K7
     1  MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PTLQLPLAND GGSRSPSSES
    61  SPQHPTPPAR PRHMLGLPST LFTPRSMESI EIDQKLQEIM KQTGYLTIGG QRYQAEINDL
   121  ENLGEMGSGT CGQVWKMRFR KTGHVIAVKQ MRRSGNKEEN KRILMDLDVV LKSHDCPYIV
   181  QCFGTFITNT DVFIAMELMG TCAEKLKKRM QGPIPERILG KMTVAIVKAL YYLKEKHGVI
   241  HRDVKPSNIL LDERGQIKLC DFGISGRLVD SKAKTRSAGC AAYMAPERID PPDPTKPDYD
   301  IRADVWSLGI SLVELATGQF PYKNCKTDFE VLTKVLQEEP PLLPGHMGFS GDFQSFVKDC
   361  LTKDHRKRPK YNKLLEHSFI KRYETLEVDV ASWFKDVMAK TESPRTSGVL SQPHLPFFR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP2K7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

50 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.23

gnomAD pLI

1

gnomAD missense Z

2.8

DepMap mean gene effect

-0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• cellular response to interleukin-1
• cellular response to lipopolysaccharide
• cellular senescence
• Fc-epsilon receptor signaling pathway
• JNK cascade
• positive regulation of DNA-templated transcription
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of JNK cascade
• positive regulation of telomere maintenance
• regulation of motor neuron apoptotic process
• response to heat
• response to osmotic stress
• response to tumor necrosis factor
• response to UV
• response to wounding
• signal transduction
• stress-activated MAPK cascade

Molecular functions

• ATP binding
• enzyme binding
• JUN kinase kinase activity
• magnesium ion binding
• MAP kinase activity
• MAP kinase kinase activity
• molecular function activator activity
• protein kinase binding
• protein phosphatase binding
• protein serine kinase activity
• protein tyrosine kinase activity

Cellular components

• cytoplasm
• cytosol
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Dual specificity MAP kinase kinase
• Protein kinase domain

KeywordsUniProt

• Acetylation
• Apoptosis
• ATP-binding
• Coiled coil
• Cytoplasm
• Kinase
• Magnesium
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Serine/threonine-protein kinase
• Stress response
• Transferase
• Tyrosine-protein kinase

InteractionsUniProt · HPA

Protein binding partners of MAP2K7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RASSF7
• VRK2
• TRIB3
• GADD45B
• MAPK8IP1