Seroatlas · Human Serome Atlas

NIPAL3

NIPA-like protein 3

Also known as: DJ462O23.2, NPAL3, NPAL3_HUMAN, SLC57A5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P499
Gene: NIPAL3
Ensembl: ENSG00000001461
Chromosome: 1
Canonical length: 406 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q6P499|NIPAL3
     1  MDGSHSAALK LQQLPPTSSS SAVSEASFSY KENLIGALLA IFGHLVVSIA LNLQKYCHIR
    61  LAGSKDPRAY FKTKTWWLGL FLMLLGELGV FASYAFAPLS LIVPLSAVSV IASAIIGIIF
   121  IKEKWKPKDF LRRYVLSFVG CGLAVVGTYL LVTFAPNSHE KMTGENVTRH LVSWPFLLYM
   181  LVEIILFCLL LYFYKEKNAN NIVVILLLVA LLGSMTVVTV KAVAGMLVLS IQGNLQLDYP
   241  IFYVMFVCMV ATAVYQAAFL SQASQMYDSS LIASVGYILS TTIAITAGAI FYLDFIGEDV
   301  LHICMFALGC LIAFLGVFLI TRNRKKPIPF EPYISMDAMP GMQNMHDKGM TVQPELKASF
   361  SYGALENNDN ISEIYAPATL PVMQEEHGSR SASGVPYRVL EHTKKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NIPAL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 60 nTPM
cerebellum: 59 nTPM
midbrain: 56 nTPM
prostate: 53 nTPM
hippocampal formation: 39 nTPM
cerebral cortex: 38 nTPM

Single-cell type

prostatic glandular cells: 612 nCPM
oligodendrocytes: 130 nCPM
megakaryocytes: 124 nCPM
lacrimal acinar cells: 121 nCPM
cone photoreceptor cells: 118 nCPM
esophageal apical cells: 116 nCPM

Immune cell

naive CD4 T-cell: 39 nTPM
T-reg: 32 nTPM
memory CD4 T-cell: 29 nTPM
naive CD8 T-cell: 25 nTPM
memory CD8 T-cell: 23 nTPM
memory B-cell: 22 nTPM

Brain region

white matter: 166 nTPM
cerebellum: 128 nTPM
basal ganglia: 127 nTPM
cerebral cortex: 127 nTPM
pons: 125 nTPM
thalamus: 125 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NIPAL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NIPAL3 as an antibody target. Whether an autoantibody or antibody against NIPAL3 could matter depends on whether native NIPAL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NIPAL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NIPAL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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