Seroatlas · Human Serome Atlas

WTAP

Pre-mRNA-splicing regulator WTAP

Also known as: FL2D_HUMAN, KIAA0105, MGC3925, Mum2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15007
Gene
WTAP
Ensembl
ENSG00000146457
Chromosome
6
Canonical length
396 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>Q15007|WTAP
     1  MTNEEPLPKK VRLSETDFKV MARDELILRW KQYEAYVQAL EGKYTDLNSN DVTGLRESEE
    61  KLKQQQQESA RRENILVMRL ATKEQEMQEC TTQIQYLKQV QQPSVAQLRS TMVDPAINLF
   121  FLKMKGELEQ TKDKLEQAQN ELSAWKFTPD SQTGKKLMAK CRMLIQENQE LGRQLSQGRI
   181  AQLEAELALQ KKYSEELKSS QDELNDFIIQ LDEEVEGMQS TILVLQQQLK ETRQQLAQYQ
   241  QQQSQASAPS TSRTTASEPV EQSEATSKDC SRLTNGPSNG SSSRQRTSGS GFHREGNTTE
   301  DDFPSSPGNG NKSSNSSEER TGRGGSGYVN QLSAGYESVD SPTGSENSLT HQSNDTDSSH
   361  DPQEEKAVSG KGNRTVGSRH VQNGLDSSVN VQGSVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WTAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
231 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 231 nTPM
  • skeletal muscle: 160 nTPM
  • urinary bladder: 96 nTPM
  • thymus: 84 nTPM
  • tonsil: 76 nTPM
  • adipose tissue: 75 nTPM

Single-cell type

  • neutrophils: 1,409 nCPM
  • monocytes: 815 nCPM
  • neutrophil progenitors: 641 nCPM
  • epicardial cells: 396 nCPM
  • endometrial glandular cells: 355 nCPM
  • epididymal basal cells: 334 nCPM

Immune cell

  • basophil: 47 nTPM
  • neutrophil: 43 nTPM
  • T-reg: 40 nTPM
  • non-classical monocyte: 38 nTPM
  • memory CD8 T-cell: 34 nTPM
  • memory CD4 T-cell: 34 nTPM

Brain region

  • hypothalamus: 52 nTPM
  • choroid plexus: 50 nTPM
  • white matter: 48 nTPM
  • thalamus: 48 nTPM
  • pons: 47 nTPM
  • cerebellum: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.13
gnomAD pLI
1
gnomAD missense Z
2.27
DepMap mean gene effect
-0.8
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Pre-mRNA-splicing regulator WTAP
  • WTAP/Mum2p family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WTAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WTAP as an antibody target. Whether an autoantibody or antibody against WTAP could matter depends on whether native WTAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WTAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WTAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WTAP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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