Seroatlas · Human Serome Atlas

SERTAD3

SERTA domain-containing protein 3

Also known as: RBT1, SRTD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJW9
Gene: SERTAD3
Ensembl: ENSG00000167565
Chromosome: 19
Canonical length: 196 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>Q9UJW9|SERTAD3
     1  MVGGLKRKHS DLEEEEERWE WSPAGLQSYQ QALLRISLDK VQRSLGPRAP SLRRHVLIHN
    61  TLQQLQAALR LAPAPALPPE PLFLGEEDFS LSATIGSILR ELDTSMDGTE PPQNPVTPLG
   121  LQNEVPPQPD PVFLEALSSR YLGDSGLDDF FLDIDTSAVE KEPARAPPEP PHNLFCAPGS
   181  WEWNELDHIM EIILGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERTAD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 40 nTPM
adipose tissue: 36 nTPM
tongue: 35 nTPM
colon: 35 nTPM
heart muscle: 33 nTPM
fallopian tube: 31 nTPM

Single-cell type

syncytiotrophoblasts: 223 nCPM
extravillous trophoblasts: 140 nCPM
esophageal apical cells: 131 nCPM
migrating cytotrophoblasts: 123 nCPM
breast hormone-responsive cells: 116 nCPM
breast secretory cells: 114 nCPM

Immune cell

neutrophil: 81 nTPM
plasmacytoid DC: 70 nTPM
eosinophil: 66 nTPM
myeloid DC: 65 nTPM
intermediate monocyte: 59 nTPM
classical monocyte: 59 nTPM

Brain region

medulla oblongata: 18 nTPM
white matter: 17 nTPM
thalamus: 14 nTPM
midbrain: 14 nTPM
spinal cord: 14 nTPM
basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0.02
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

SERTA domain
SERTA motif
SERTA domain-containing protein 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERTAD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PB1
PB2
RPA2
USHBP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERTAD3 as an antibody target. Whether an autoantibody or antibody against SERTAD3 could matter depends on whether native SERTAD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERTAD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERTAD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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