Seroatlas · Human Serome Atlas

BLTP3A

Bridge-like lipid transfer protein family member 3A

Also known as: BLT3A_HUMAN, C6orf107, dJ349A12.1, FLJ20302, UHRF1BP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6BDS2
Gene: BLTP3A
Ensembl: ENSG00000065060
Chromosome: 6
Canonical length: 1440 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables histone deacetylase binding activity and identical protein binding activity. Located in late endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1440 residues, UniProt reviewed canonical sequence.

>Q6BDS2|BLTP3A
     1  MAGIIKKQIL KHLSRFTKNL SPDKINLSTL KGEGQLTNLE LDEEVLQNVL ELPTWLAITR
    61  VYCNRASIRI QWTKLKTHPI CLCLDKVEVE MKTCEDPRPP NGQSPIALAS GQSEYGFAEK
   121  VVEGMFIIVN SITIKIHSKA FHASFELWQL QGYSVNPNWQ QSDLRLTRIT DPCRGEVLTF
   181  KEITWQTLRI EADATDNGDQ DPVTTPLRLI TNQGRIQIAL KRRTKDCNVI SSKLMFLLDD
   241  LLWVLTDSQL KAMMKYAESL SEAMEKSAHQ RKSLAPEPVQ ITPPAPSAQQ SWAQAFGGSQ
   301  GNSNSSSSRL SQYFEKFDVK ESSYHLLISR LDLHICDDSQ SREPGVSANR LMGGAMQLTF
   361  RKMAFDYYPF HWAGDSCKHW VRHCEAMETR GQWAQKLVME FQSKMEKWHE ETGLKPPWHL
   421  GVDSLFRRKA DSLSSPRKNP LERSPSQGRQ PAFQPPAWNR LRSSCMVVRV DDLDIHQVST
   481  AGQPSKKPST LLSCSRKLHN LPTQVSAIHI EFTEYYFPDN QELPVPCPNL YIQLNGLTFT
   541  MDPVSLLWGN LFCLDLYRSL EQFKAIYKLE DSSQKDEHLD IRLDAFWLKV SFPLEKRERA
   601  ELHRPQALVF SASGMIATNT RHAPHCSCSD LQSLFRGFAA AEFFHSNYDH FPKVPGGFSL
   661  LHMLFLHHAF QMDSCLPQPN TLPPQRPKAS WDLWSVHFTQ ISLDFEGTEN FKGHTLNFVA
   721  PFPLSIWACL PLRWQQAQAR KLLLASEGRL KPSASFGSPV QSEALAPDSM SHPRSKTEHD
   781  LKSLSGLTEV MEILKEGSSG MDNKGPLTEL EDVADVHMLV HSPAHVRVRL DHYQYLALLR
   841  LKEVLQRLQE QLTKDTESMT GSPLQNQTAC IGVLFPSAEV ALLMHPAPGA VDADSAGSDS
   901  TSLVDSELSP SEDRELKSDA SSDQGPASPE KVLEESSIEN QDVSQERPHS NGELQDSGPL
   961  AQQLAGKGHE AVESLQAKKL SRTQASSSPA ALKPPAGRET AVNGQGELIP LKNIEGELSS
  1021  AIHMTKDATK EALHATMDLT KEAVSLTKDA FSLGRDRMTS TMHKMLSLPP AKEPMAKTDE
  1081  GVAAPVSGGA ARLRFFSMKR TVSQQSFDGV SLDSSGPEDR ISVDSDGSDS FVMLLESESG
  1141  PESVPPGSLS NVSDNAGVQG SPLVNNYGQG SPAANSSVSP SGEDLIFHPV SVLVLKVNEV
  1201  SFGIEVRGED LTVALQAEEL TLQQLGTVGL WQFLHGQCPG TCFQESSTLK TGHIRPAVGL
  1261  RFEVGPGAAV HSPLASQNGF LHLLLHGCDL ELLTSVLSGL GPFLEDEEIP VVVPMQIELL
  1321  NSSITLKDDI PPIYPTSPGP IPITLAMEHV VLKRSDDGVF HIGAAAQDKP SAEVLKSEKR
  1381  QPPKEQVFLV PTGEVFEQQV KELPILQKEL IETKQALANA NQDKEKLLQE IRKYNPFFEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BLTP3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 13 nTPM
bone marrow: 12 nTPM
testis: 11 nTPM
parathyroid gland: 8 nTPM
pancreas: 7.1 nTPM
tongue: 6.6 nTPM

Single-cell type

myonuclei: 120 nCPM
sertoli cells: 108 nCPM
platelets: 95 nCPM
cardiomyocytes: 86 nCPM
gonadotrophs: 80 nCPM
kupffer cells: 77 nCPM

Immune cell

non-classical monocyte: 1.2 nTPM
intermediate monocyte: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM
NK-cell: 0.3 nTPM

Brain region

cerebellum: 19 nTPM
choroid plexus: 14 nTPM
pons: 13 nTPM
midbrain: 13 nTPM
white matter: 13 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

late endosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BLTP3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UHRF1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BLTP3A as an antibody target. Whether an autoantibody or antibody against BLTP3A could matter depends on whether native BLTP3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BLTP3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BLTP3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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