Seroatlas · Human Serome Atlas

QRICH1

Transcriptional regulator QRICH1

Also known as: AB-DIP, FLJ20259, QRIC1_HUMAN, VERBRAS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TAL8
Gene: QRICH1
Ensembl: ENSG00000198218
Chromosome: 3
Canonical length: 776 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Enables DNA binding activity. Involved in intracellular signal transduction; positive regulation of DNA-templated transcription; and positive regulation of apoptotic process. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

776 residues, UniProt reviewed canonical sequence.

>Q2TAL8|QRICH1
     1  MNNSLENTIS FEEYIRVKAR SVPQHRMKEF LDSLASKGPE ALQEFQQTAT TTMVYQQGGN
    61  CIYTDSTEVA GSLLELACPV TTSVQPQTQQ EQQIQVQQPQ QVQVQVQVQQ SPQQVSAQLS
   121  PQLTVHQPTE QPIQVQVQIQ GQAPQSAAPS IQTPSLQSPS PSQLQAAQIQ VQHVQAAQQI
   181  QAAEIPEEHI PHQQIQAQLV AGQSLAGGQQ IQIQTVGALS PPPSQQGSPR EGERRVGTAS
   241  VLQPVKKRKV DMPITVSYAI SGQPVATVLA IPQGQQQSYV SLRPDLLTVD SAHLYSATGT
   301  ITSPTGETWT IPVYSAQPRG DPQQQSITHI AIPQEAYNAV HVSGSPTALA AVKLEDDKEK
   361  MVGTTSVVKN SHEEVVQTLA NSLFPAQFMN GNIHIPVAVQ AVAGTYQNTA QTVHIWDPQQ
   421  QPQQQTPQEQ TPPPQQQQQQ LQVTCSAQTV QVAEVEPQSQ PQPSPELLLP NSLKPEEGLE
   481  VWKNWAQTKN AELEKDAQNR LAPIGRRQLL RFQEDLISSA VAELNYGLCL MTREARNGEG
   541  EPYDPDVLYY IFLCIQKYLF ENGRVDDIFS DLYYVRFTEW LHEVLKDVQP RVTPLGYVLP
   601  SHVTEEMLWE CKQLGAHSPS TLLTTLMFFN TKYFLLKTVD QHMKLAFSKV LRQTKKNPSN
   661  PKDKSTSIRY LKALGIHQTG QKVTDDMYAE QTENPENPLR CPIKLYDFYL FKCPQSVKGR
   721  NDTFYLTPEP VVAPNSPIWY SVQPISREQM GQMLTRILVI REIQEAIAVA NASTMH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against QRICH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

thymus: 41 nTPM
bone marrow: 38 nTPM
skin: 37 nTPM
cerebellum: 36 nTPM
skeletal muscle: 35 nTPM
testis: 35 nTPM

Single-cell type

choroid plexus epithelial cells: 91 nCPM
distal convoluted tubule cells: 74 nCPM
proximal tubule cells: 68 nCPM
renal connecting tubule cells: 65 nCPM
renal collecting duct intercalated cells: 64 nCPM
brain excitatory neurons: 63 nCPM

Immune cell

non-classical monocyte: 28 nTPM
MAIT T-cell: 19 nTPM
naive CD8 T-cell: 18 nTPM
memory CD8 T-cell: 18 nTPM
T-reg: 17 nTPM
myeloid DC: 17 nTPM

Brain region

cerebral cortex: 39 nTPM
cerebellum: 38 nTPM
choroid plexus: 36 nTPM
white matter: 32 nTPM
basal ganglia: 32 nTPM
hypothalamus: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about QRICH1.

Disease | AllUniProt

Conditions QRICH1 is implicated in, by any mechanism.

Ververi-Brady syndrome 1 (VERBRAS1) MIM:617982

Disease | GeneticClinVar

73 pathogenic / likely-pathogenic of 248 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Ververi-Brady syndrome
Inborn genetic diseases
Ververi-Brady syndrome 1
Intellectual disability
Mild intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 1
gnomAD missense Z: 3.71
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of QRICH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads QRICH1 as an antibody target. Whether an autoantibody or antibody against QRICH1 could matter depends on whether native QRICH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

QRICH1 is annotated at the cell surface, where native QRICH1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label QRICH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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