Seroatlas · Human Serome Atlas

PLAA

Phospholipase A-2-activating protein

Also known as: DOA1, FLJ11281, FLJ12699, PLA2P, PLAP, PLAP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y263
Gene
PLAA
Ensembl
ENSG00000137055
Chromosome
9
Canonical length
795 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin binding activity. Involved in cellular response to lipopolysaccharide; macroautophagy; and positive regulation of phospholipase A2 activity. Located in cytoplasm; extracellular exosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

795 residues, UniProt reviewed canonical sequence.

>Q9Y263|PLAA
     1  MTSGATRYRL SCSLRGHELD VRGLVCCAYP PGAFVSVSRD RTTRLWAPDS PNRSFTEMHC
    61  MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD SPMPLYILKG HKNTVCSLSS
   121  GKFGTLLSGS WDTTAKVWLN DKCMMTLQGH TAAVWAVKIL PEQGLMLTGS ADKTVKLWKA
   181  GRCERTFSGH EDCVRGLAIL SETEFLSCAN DASIRRWQIT GECLEVYYGH TNYIYSISVF
   241  PNCRDFVTTA EDRSLRIWKH GECAQTIRLP AQSIWCCCVL DNGDIVVGAS DGIIRVFTES
   301  EDRTASAEEI KAFEKELSHA TIDSKTGDLG DINAEQLPGR EHLNEPGTRE GQTRLIRDGE
   361  KVEAYQWSVS EGRWIKIGDV VGSSGANQQT SGKVLYEGKE FDYVFSIDVN EGGPSYKLPY
   421  NTSDDPWLTA YNFLQKNDLN PMFLDQVAKF IIDNTKGQML GLGNPSFSDP FTGGGRYVPG
   481  SSGSSNTLPT ADPFTGAGRY VPGSASMGTT MAGVDPFTGN SAYRSAASKT MNIYFPKKEA
   541  VTFDQANPTQ ILGKLKELNG TAPEEKKLTE DDLILLEKIL SLICNSSSEK PTVQQLQILW
   601  KAINCPEDIV FPALDILRLS IKHPSVNENF CNEKEGAQFS SHLINLLNPK GKPANQLLAL
   661  RTFCNCFVGQ AGQKLMMSQR ESLMSHAIEL KSGSNKNIHI ALATLALNYS VCFHKDHNIE
   721  GKAQCLSLIS TILEVVQDLE ATFRLLVALG TLISDDSNAV QLAKSLGVDS QIKKYSSVSE
   781  PAKVSECCRF ILNLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLAA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 48 nTPM
  • bone marrow: 40 nTPM
  • tongue: 27 nTPM
  • liver: 20 nTPM
  • testis: 19 nTPM
  • smooth muscle: 18 nTPM

Single-cell type

  • neutrophils: 140 nCPM
  • adrenal cortex cells: 113 nCPM
  • syncytiotrophoblasts: 106 nCPM
  • neutrophil progenitors: 103 nCPM
  • esophageal apical cells: 88 nCPM
  • erythrocyte progenitors: 74 nCPM

Immune cell

  • basophil: 22 nTPM
  • non-classical monocyte: 21 nTPM
  • eosinophil: 21 nTPM
  • intermediate monocyte: 18 nTPM
  • T-reg: 18 nTPM
  • NK-cell: 15 nTPM

Brain region

  • cerebral cortex: 25 nTPM
  • hypothalamus: 25 nTPM
  • choroid plexus: 25 nTPM
  • white matter: 25 nTPM
  • hippocampal formation: 24 nTPM
  • pons: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLAA.

Disease | AllUniProt

Conditions PLAA is implicated in, by any mechanism.

  • Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA) MIM:617527

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 605 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.47
gnomAD missense Z
1.1
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLAA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLAA as an antibody target. Whether an autoantibody or antibody against PLAA could matter depends on whether native PLAA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLAA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLAA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLAA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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