Seroatlas · Human Serome Atlas

VCPIP1

Deubiquitinating protein VCPIP1

Also known as: DUBA3, FLJ23132, KIAA1850, VCIP1_HUMAN, VCIP135

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JH7
Gene: VCPIP1
Ensembl: ENSG00000175073
Chromosome: 8
Canonical length: 1222 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Centrosome,Cytosol

OverviewNCBI Gene

Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination; protein-DNA covalent cross-linking repair; and regulation of protein localization to chromatin. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1222 residues, UniProt reviewed canonical sequence.

>Q96JH7|VCPIP1
     1  MSQPPPPPPP LPPPPPPPEA PQTPSSLASA AASGGLLKRR DRRILSGSCP DPKCQARLFF
    61  PASGSVSIEC TECGQRHEQQ QLLGVEEVTD PDVVLHNLLR NALLGVTGAP KKNTELVKVM
   121  GLSNYHCKLL SPILARYGMD KQTGRAKLLR DMNQGELFDC ALLGDRAFLI EPEHVNTVGY
   181  GKDRSGSLLY LHDTLEDIKR ANKSQECLIP VHVDGDGHCL VHAVSRALVG RELFWHALRE
   241  NLKQHFQQHL ARYQALFHDF IDAAEWEDII NECDPLFVPP EGVPLGLRNI HIFGLANVLH
   301  RPIILLDSLS GMRSSGDYSA TFLPGLIPAE KCTGKDGHLN KPICIAWSSS GRNHYIPLVG
   361  IKGAALPKLP MNLLPKAWGV PQDLIKKYIK LEEDGGCVIG GDRSLQDKYL LRLVAAMEEV
   421  FMDKHGIHPS LVADVHQYFY RRTGVIGVQP EEVTAAAKKA VMDNRLHKCL LCGALSELHV
   481  PPEWLAPGGK LYNLAKSTHG QLRTDKNYSF PLNNLVCSYD SVKDVLVPDY GMSNLTACNW
   541  CHGTSVRKVR GDGSIVYLDG DRTNSRSTGG KCGCGFKHFW DGKEYDNLPE AFPITLEWGG
   601  RVVRETVYWF QYESDSSLNS NVYDVAMKLV TKHFPGEFGS EILVQKVVHT ILHQTAKKNP
   661  DDYTPVNIDG AHAQRVGDVQ GQESESQLPT KIILTGQKTK TLHKEELNMS KTERTIQQNI
   721  TEQASVMQKR KTEKLKQEQK GQPRTVSPST IRDGPSSAPA TPTKAPYSPT TSKEKKIRIT
   781  TNDGRQSMVT LKSSTTFFEL QESIAREFNI PPYLQCIRYG FPPKELMPPQ AGMEKEPVPL
   841  QHGDRITIEI LKSKAEGGQS AAAHSAHTVK QEDIAVTGKL SSKELQEQAE KEMYSLCLLA
   901  TLMGEDVWSY AKGLPHMFQQ GGVFYSIMKK TMGMADGKHC TFPHLPGKTF VYNASEDRLE
   961  LCVDAAGHFP IGPDVEDLVK EAVSQVRAEA TTRSRESSPS HGLLKLGSGG VVKKKSEQLH
  1021  NVTAFQGKGH SLGTASGNPH LDPRARETSV VRKHNTGTDF SNSSTKTEPS VFTASSSNSE
  1081  LIRIAPGVVT MRDGRQLDPD LVEAQRKKLQ EMVSSIQASM DRHLRDQSTE QSPSDLPQRK
  1141  TEVVSSSAKS GSLQTGLPES FPLTGGTENL NTETTDGCVA DALGAAFATR SKAQRGNSVE
  1201  ELEEMDSQDA EMTNTTEPMD HS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VCPIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 19 nTPM
spleen: 8.3 nTPM
lymph node: 8 nTPM
tonsil: 7.3 nTPM
liver: 6.6 nTPM
appendix: 5.7 nTPM

Single-cell type

neutrophils: 162 nCPM
neutrophil progenitors: 110 nCPM
kupffer cells: 87 nCPM
platelets: 52 nCPM
monocyte progenitors: 52 nCPM
monocytes: 47 nCPM

Immune cell

basophil: 9.9 nTPM
neutrophil: 9.7 nTPM
non-classical monocyte: 8.4 nTPM
eosinophil: 5.9 nTPM
intermediate monocyte: 4.3 nTPM
gdT-cell: 3.4 nTPM

Brain region

thalamus: 23 nTPM
cerebral cortex: 22 nTPM
hypothalamus: 22 nTPM
pons: 21 nTPM
cerebellum: 21 nTPM
white matter: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.12
gnomAD pLI: 1
gnomAD missense Z: 3.56
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cysteine-type deubiquitinase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

OTU domain
Ubiquitin-like domain superfamily
OTU1, Ubl domain
OTU-like cysteine protease
OTU1, UBXL domain
Deubiquitinating protein VCPIP1
Deubiquitinating protein VCPIP1, N-terminal
VCIP135 N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VCPIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VCPIP1 as an antibody target. Whether an autoantibody or antibody against VCPIP1 could matter depends on whether native VCPIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VCPIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VCPIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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