Seroatlas · Human Serome Atlas

SGTB

Small glutamine-rich tetratricopeptide repeat-containing protein beta

Also known as: FLJ39002, Sgt2, SGTB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EQ0
Gene: SGTB
Ensembl: ENSG00000197860
Chromosome: 5
Canonical length: 304 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles,Microtubules,Primary cilium,Basal body
Quaternary structure: Homooligomer

OverviewNCBI Gene

Predicted to enable molecular adaptor activity. Predicted to be involved in post-translational protein targeting to endoplasmic reticulum membrane. Predicted to be part of TRC complex. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q96EQ0|SGTB
     1  MSSIKHLVYA VIRFLREQSQ MDTYTSDEQE SLEVAIQCLE TVFKISPEDT HLAVSQPLTE
    61  MFTSSFCKND VLPLSNSVPE DVGKADQLKD EGNNHMKEEN YAAAVDCYTQ AIELDPNNAV
   121  YYCNRAAAQS KLGHYTDAIK DCEKAIAIDS KYSKAYGRMG LALTALNKFE EAVTSYQKAL
   181  DLDPENDSYK SNLKIAEQKL REVSSPTGTG LSFDMASLIN NPAFISMAAS LMQNPQVQQL
   241  MSGMMTNAIG GPAAGVGGLT DLSSLIQAGQ QFAQQIQQQN PELIEQLRNH IRSRSFSSSA
   301  EEHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SGTB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 30 nTPM
retina: 15 nTPM
amygdala: 11 nTPM
cerebellum: 11 nTPM
midbrain: 11 nTPM
hypothalamus: 10 nTPM

Single-cell type

neutrophils: 114 nCPM
retinal horizontal cells: 84 nCPM
müller glia: 78 nCPM
neutrophil progenitors: 63 nCPM
monocytes: 56 nCPM
t-cells: 49 nCPM

Immune cell

T-reg: 14 nTPM
basophil: 10 nTPM
intermediate monocyte: 6.7 nTPM
naive CD4 T-cell: 6.7 nTPM
memory CD4 T-cell: 6.3 nTPM
neutrophil: 5.8 nTPM

Brain region

cerebral cortex: 64 nTPM
white matter: 44 nTPM
basal ganglia: 43 nTPM
pons: 43 nTPM
hypothalamus: 42 nTPM
thalamus: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.04
gnomAD missense Z: 2.03
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SGTB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SGTB as an antibody target. Whether an autoantibody or antibody against SGTB could matter depends on whether native SGTB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SGTB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SGTB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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