Seroatlas · Human Serome Atlas

SHARPIN

Sharpin

Also known as: DKFZP434N1923, SHRPN_HUMAN, SIPL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H0F6
Gene
SHARPIN
Ensembl
ENSG00000179526
Chromosome
8
Canonical length
387 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables polyubiquitin modification-dependent protein binding activity. Involved in defense response to bacterium; protein linear polyubiquitination; and regulation of signal transduction. Located in cytosol. Part of LUBAC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>Q9H0F6|SHARPIN
     1  MAPPAGGAAA AASDLGSAAV LLAVHAAVRP LGAGPDAEAQ LRRLQLSADP ERPGRFRLEL
    61  LGAGPGAVNL EWPLESVSYT IRGPTQHELQ PPPGGPGTLS LHFLNPQEAQ RWAVLVRGAT
   121  VEGQNGSKSN SPPALGPEAC PVSLPSPPEA STLKGPPPEA DLPRSPGNLT EREELAGSLA
   181  RAIAGGDEKG AAQVAAVLAQ HRVALSVQLQ EACFPPGPIR LQVTLEDAAS AASAASSAHV
   241  ALQVHPHCTV AALQEQVFSE LGFPPAVQRW VIGRCLCVPE RSLASYGVRQ DGDPAFLYLL
   301  SAPREAPATG PSPQHPQKMD GELGRLFPPS LGLPPGPQPA ASSLPSPLQP SWSCPSCTFI
   361  NAPDRPGCEM CSTQRPCTWD PLAAAST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHARPIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
105 nTPM

Expression across tissuesHPA

Tissue

  • testis: 105 nTPM
  • skeletal muscle: 55 nTPM
  • heart muscle: 52 nTPM
  • adrenal gland: 48 nTPM
  • choroid plexus: 48 nTPM
  • colon: 45 nTPM

Single-cell type

  • late spermatids: 2,268 nCPM
  • late primary spermatocytes: 489 nCPM
  • early spermatids: 388 nCPM
  • cardiomyocytes: 135 nCPM
  • esophageal apical cells: 123 nCPM
  • differentiating spermatogonia: 107 nCPM

Immune cell

  • eosinophil: 54 nTPM
  • plasmacytoid DC: 43 nTPM
  • intermediate monocyte: 41 nTPM
  • memory CD8 T-cell: 38 nTPM
  • non-classical monocyte: 35 nTPM
  • T-reg: 34 nTPM

Brain region

  • medulla oblongata: 42 nTPM
  • pons: 38 nTPM
  • midbrain: 37 nTPM
  • thalamus: 37 nTPM
  • basal ganglia: 37 nTPM
  • cerebral cortex: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SHARPIN.

Disease | AllUniProt

Conditions SHARPIN is implicated in, by any mechanism.

  • Autoinflammation with episodic fever and immune dysregulation (AIFID) MIM:620795

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Autoinflammation with episodic fever and immune dysregulation
  • Sharpin-related autoinflammatory syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
gnomAD missense Z
-0.04
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SHARPIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHARPIN as an antibody target. Whether an autoantibody or antibody against SHARPIN could matter depends on whether native SHARPIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHARPIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHARPIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SHARPIN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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