Seroatlas · Human Serome Atlas

SDC2

Syndecan-2

Also known as: CD362, fibroglycan, HSPG, HSPG1, SDC2_HUMAN, SYND2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P34741
Gene
SDC2
Ensembl
ENSG00000169439
Chromosome
8
Canonical length
201 aa
Protein class
CD markers, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>P34741|SDC2
     1  MRRAWILLTL GLVACVSAES RAELTSDKDM YLDNSSIEEA SGVYPIDDDD YASASGSGAD
    61  EDVESPELTT SRPLPKILLT SAAPKVETTT LNIQNKIPAQ TKSPEETDKE KVHLSDSERK
   121  MDPAEEDTNV YTEKHSDSLF KRTEVLAAVI AGGVIGFLFA IFLILLLVYR MRKKDEGSYD
   181  LGERKPSSAA YQKAPTKEFY A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
430 nTPM

Expression across tissuesHPA

Tissue

  • liver: 430 nTPM
  • thyroid gland: 398 nTPM
  • ovary: 191 nTPM
  • blood vessel: 188 nTPM
  • cervix: 147 nTPM
  • placenta: 117 nTPM

Single-cell type

  • breast lactating cells: 359 nCPM
  • hepatocytes: 328 nCPM
  • decidual stromal cells: 310 nCPM
  • fibro-adipogenic progenitors: 307 nCPM
  • gonadotrophs: 295 nCPM
  • pituicytes/fscs: 282 nCPM

Immune cell

  • neutrophil: 14 nTPM
  • classical monocyte: 2 nTPM
  • myeloid DC: 1.3 nTPM
  • total PBMC: 0.6 nTPM
  • intermediate monocyte: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM

Brain region

  • hypothalamus: 80 nTPM
  • thalamus: 73 nTPM
  • midbrain: 71 nTPM
  • medulla oblongata: 58 nTPM
  • basal ganglia: 57 nTPM
  • spinal cord: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0.4
gnomAD missense Z
0.46
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SDC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDC2 as an antibody target. Whether an autoantibody or antibody against SDC2 could matter depends on whether native SDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDC2 is annotated at the cell surface, where native SDC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SDC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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