Seroatlas · Human Serome Atlas

UFM1

Ubiquitin-fold modifier 1

Also known as: bA131P10.1, C13orf20, UFM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61960
Gene
UFM1
Ensembl
ENSG00000120686
Chromosome
13
Canonical length
85 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008]

Canonical amino-acid sequenceUniProt

85 residues, UniProt reviewed canonical sequence.

>P61960|UFM1
     1  MSKVSFKITL TSDPRLPYKV LSVPESTPFT AVLKFAAEEF KVPAATSAII TNDGIGINPA
    61  QTAGNVFLKH GSELRIIPRD RVGSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UFM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
94 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 94 nTPM
  • epididymis: 61 nTPM
  • pancreas: 61 nTPM
  • salivary gland: 55 nTPM
  • endometrium: 55 nTPM
  • spinal cord: 50 nTPM

Single-cell type

  • esophageal apical cells: 309 nCPM
  • plasma cells: 305 nCPM
  • gastric progenitor cells: 250 nCPM
  • pancreatic acinar cells: 239 nCPM
  • parietal cells: 225 nCPM
  • gastric chief cells: 223 nCPM

Immune cell

  • basophil: 72 nTPM
  • plasmacytoid DC: 45 nTPM
  • intermediate monocyte: 42 nTPM
  • eosinophil: 41 nTPM
  • non-classical monocyte: 40 nTPM
  • memory B-cell: 40 nTPM

Brain region

  • white matter: 60 nTPM
  • hypothalamus: 58 nTPM
  • choroid plexus: 55 nTPM
  • spinal cord: 55 nTPM
  • medulla oblongata: 52 nTPM
  • pons: 51 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UFM1.

Disease | AllUniProt

Conditions UFM1 is implicated in, by any mechanism.

  • Leukodystrophy, hypomyelinating, 14 (HLD14) MIM:617899

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 60 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0.16
gnomAD missense Z
0.62
DepMap mean gene effect
-0.5
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UFM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UFM1 as an antibody target. Whether an autoantibody or antibody against UFM1 could matter depends on whether native UFM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UFM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UFM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UFM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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