Seroatlas · Human Serome Atlas

SLBP

Histone RNA hairpin-binding protein

Also known as: HBP, SLBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14493
Gene
SLBP
Ensembl
ENSG00000163950
Chromosome
4
Canonical length
270 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q14493|SLBP
     1  MACRPRSPPR HQSRCDGDAS PPSPARWSLG RKRRADGRRW RPEDAEEAEH RGAERRPESF
    61  TTPEGPKPRS RCSDWASAVE EDEMRTRVNK EMARYKRKLL INDFGRERKS SSGSSDSKES
   121  MSTVPADFET DESVLMRRQK QINYGKNTIA YDRYIKEVPR HLRQPGIHPK TPNKFKKYSR
   181  RSWDQQIKLW KVALHFWDPP AEEGCDLQEI HPVDLESAES SSEPQTSSQD DFDVYSGTPT
   241  KVRHMDSQVE DEFDLEACLT EPLRDFSAMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
108 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 108 nTPM
  • lymph node: 67 nTPM
  • tonsil: 65 nTPM
  • testis: 59 nTPM
  • thymus: 50 nTPM
  • placenta: 39 nTPM

Single-cell type

  • oocytes: 419 nCPM
  • differentiating spermatogonia: 383 nCPM
  • early primary spermatocytes: 368 nCPM
  • cytotrophoblasts: 219 nCPM
  • erythrocyte progenitors: 181 nCPM
  • esophageal basal cells: 171 nCPM

Immune cell

  • neutrophil: 96 nTPM
  • T-reg: 78 nTPM
  • total PBMC: 76 nTPM
  • classical monocyte: 66 nTPM
  • memory CD8 T-cell: 65 nTPM
  • memory CD4 T-cell: 60 nTPM

Brain region

  • hypothalamus: 45 nTPM
  • cerebral cortex: 41 nTPM
  • white matter: 38 nTPM
  • basal ganglia: 36 nTPM
  • pons: 36 nTPM
  • midbrain: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0.07
gnomAD missense Z
0.53
DepMap mean gene effect
-0.69
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Histone RNA stem-loop-binding protein SLBP1/SLBP2
  • Histone RNA hairpin-binding protein, RNA-binding domain
  • SLBP, RNA-binding domain superfamily
  • Histone RNA hairpin-binding protein RNA-binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLBP as an antibody target. Whether an autoantibody or antibody against SLBP could matter depends on whether native SLBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLBP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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