Seroatlas · Human Serome Atlas

ZDHHC3

Palmitoyltransferase ZDHHC3

Also known as: DHHC3, GODZ, ZDHC3_HUMAN, ZNF373

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYG2
Gene: ZDHHC3
Ensembl: ENSG00000163812
Chromosome: 3
Canonical length: 299 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables palmitoyltransferase activity. Involved in several processes, including protein localization to membrane; protein localization to photoreceptor outer segment; and regulation of signal transduction. Located in membrane. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q9NYG2|ZDHHC3
     1  MMLIPTHHFR NIERKPEYLQ PEKCVPPPYP GPVGTMWFIR DGCGIACAIV TWFLVLYAEF
    61  VVLFVMLIPS RDYVYSIING IVFNLLAFLA LASHCRAMLT DPGAVPKGNA TKEFIESLQL
   121  KPGQVVYKCP KCCSIKPDRA HHCSVCKRCI RKMDHHCPWV NNCVGENNQK YFVLFTMYIA
   181  LISLHALIMV GFHFLHCFEE DWTKCSSFSP PTTVILLILL CFEGLLFLIF TSVMFGTQVH
   241  SICTDETGIE QLKKEERRWA KKTKWMNMKA VFGHPFSLGW ASPFATPDQG KADPYQYVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDHHC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 60 nTPM
testis: 59 nTPM
skin: 52 nTPM
colon: 45 nTPM
rectum: 45 nTPM
esophagus: 42 nTPM

Single-cell type

late spermatids: 1,959 nCPM
early spermatids: 557 nCPM
late primary spermatocytes: 243 nCPM
renal collecting duct intercalated cells: 208 nCPM
esophageal apical cells: 168 nCPM
esophageal suprabasal cells: 138 nCPM

Immune cell

basophil: 44 nTPM
eosinophil: 29 nTPM
neutrophil: 22 nTPM
myeloid DC: 22 nTPM
classical monocyte: 20 nTPM
non-classical monocyte: 15 nTPM

Brain region

pons: 40 nTPM
spinal cord: 37 nTPM
thalamus: 36 nTPM
cerebellum: 36 nTPM
medulla oblongata: 36 nTPM
midbrain: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.03
gnomAD missense Z: 2.08
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZDHHC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TNFRSF10A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDHHC3 as an antibody target. Whether an autoantibody or antibody against ZDHHC3 could matter depends on whether native ZDHHC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDHHC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDHHC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...