MAPK8IP2

Protein identityUniProt · HPA

UniProt accession

Q13387

Gene

MAPK8IP2

Ensembl

ENSG00000008735

Chromosome

22

Canonical length

824 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]

Canonical amino-acid sequenceUniProt

824 residues, UniProt reviewed canonical sequence.

>Q13387|MAPK8IP2
     1  MADRAEMFSL STFHSLSPPG CRPPQDISLE EFDDEDLSEI TDDCGLGLSY DSDHCEKDSL
    61  SLGRSEQPHP ICSFQDDFQE FEMIDDNEEE DDEDEEEEEE EEEGDGEGQE GGDPGSEAPA
   121  PGPLIPSPSV EEPHKHRPTT LRLTTLGAQD SLNNNGGFDL VRPASWQETA LCSPAPEALR
   181  ELPGPLPATD TGPGGAQSPV RPGCDCEGNR PAEPPAPGGT SPSSDPGIEA DLRSRSSGGR
   241  GGRRSSQELS SPGSDSEDAG GARLGRMISS ISETELELSS DGGSSSSGRS SHLTNSIEEA
   301  SSPASEPEPP REPPRRPAFL PVGPDDTNSE YESGSESEPD LSEDADSPWL LSNLVSRMIS
   361  EGSSPIRCPG QCLSPAPRPP GEPVSPAGGA AQDSQDPEAA AGPGGVELVD METLCAPPPP
   421  APAAPRPGPA QPGPCLFLSN PTRDTITPLW AAPGRAARPG RACSAACSEE EDEEDDEEEE
   481  DAEDSAGSPG GRGTGPSAPR DASLVYDAVK YTLVVDEHTQ LELVSLRRCA GLGHDSEEDS
   541  GGEASEEEAG AALLGGGQVS GDTSPDSPDL TFSKKFLNVF VNSTSRSSST ESFGLFSCLV
   601  NGEEREQTHR AVFRFIPRHP DELELDVDDP VLVEAEEDDF WFRGFNMRTG ERGVFPAFYA
   661  HAVPGPAKDL LGSKRSPCWV ERFDVQFLGS VEVPCHQGNG ILCAAMQKIA TARKLTVHLR
   721  PPASCDLEIS LRGVKLSLSG GGPEFQRCSH FFQMKNISFC GCHPRNSCYF GFITKHPLLS
   781  RFACHVFVSQ ESMRPVAQSV GRAFLEYYQE HLAYACPTED IYLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPK8IP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

103 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.1

gnomAD pLI

1

gnomAD missense Z

2.56

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• behavioral fear response
• dendrite morphogenesis
• JNK cascade
• MAPK cascade
• mating behavior
• modulation of excitatory postsynaptic potential
• negative regulation of apoptotic signaling pathway
• positive regulation of stress-activated MAPK cascade
• regulation of JNK cascade
• regulation of synaptic transmission, glutamatergic
• signal complex assembly
• social behavior
• nonassociative learning

Molecular functions

• amyloid-beta binding
• JUN kinase binding
• kinesin binding
• MAP-kinase scaffold activity
• protein kinase activator activity
• protein kinase binding
• protein-containing complex binding
• structural molecule activity

Cellular components

• cytoplasm
• neuronal cell body
• postsynaptic density
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• SH3 domain
• PTB/PI domain
• PH-like domain superfamily
• JNK-interacting protein 1
• Phosphotyrosine interaction domain (PTB/PID)
• Variant SH3 domain
• JIP2, SH3 domain

KeywordsUniProt

• Cytoplasm
• Phosphoprotein
• SH3 domain

InteractionsUniProt · HPA

Protein binding partners of MAPK8IP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DCLK2
• FGF13
• SH3RF2
• TIAM1
• TIAM2
• MAPK13
• EGFR
• UBD