Seroatlas · Human Serome Atlas

TEX11

Testis-expressed protein 11

Also known as: MZIP4, Spo22, TEX11_HUMAN, TGC1, TSGA3, ZIP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYF3
Gene: TEX11
Ensembl: ENSG00000120498
Chromosome: X
Canonical length: 940 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

940 residues, UniProt reviewed canonical sequence.

>Q8IYF3|TEX11
     1  MISAHCNLRL LCSSDSSASA SQVAGTTEVV ENLVTNDNSP NIPEAIDRLF SDIANINRES
    61  MAEITDIQIE EMAVNLWNWA LTIGGGWLVN EEQKIRLHYV ACKLLSMCEA SFASEQSIQR
   121  LIMMNMRIGK EWLDAGNFLI ADECFQAAVA SLEQLYVKLI QRSSPEADLT MEKITVESDH
   181  FRVLSYQAES AVAQGDFQRA SMCVLQCKDM LMRLPQMTSS LHHLCYNFGV ETQKNNKYEE
   241  SSFWLSQSYD IGKMDKKSTG PEMLAKVLRL LATNYLDWDD TKYYDKALNA VNLANKEHLS
   301  SPGLFLKMKI LLKGETSNEE LLEAVMEILH LDMPLDFCLN IAKLLMDHER ESVGFHFLTI
   361  IHERFKSSEN IGKVLILHTD MLLQRKEELL AKEKIEEIFL AHQTGRQLTA ESMNWLHNIL
   421  WRQAASSFEV QNYTDALQWY YYSLRFYSTD EMDLDFTKLQ RNMACCYLNL QQLDKAKEAV
   481  AEAERHDPRN VFTQFYIFKI AVIEGNSERA LQAIITLENI LTDEESEDND LVAERGSPTM
   541  LLSLAAQFAL ENGQQIVAEK ALEYLAQHSE DQEQVLTAVK CLLRFLLPKI AEMPESEDKK
   601  KEMDRLLTCL NRAFVKLSQP FGEEALSLES RANEAQWFRK TAWNLAVQCD KDPVMMREFF
   661  ILSYKMSQFC PSDQVILIAR KTCLLMAVAV DLEQGRKAST AFEQTMFLSR ALEEIQTCND
   721  IHNFLKQTGT FSNDSCEKLL LLYEFEVRAK LNDPLLESFL ESVWELPHLE TKTFETIAII
   781  AMEKPAHYPL IALKALKKAL LLYKKEEPID ISQYSKCMHN LVNLSVPDGA SNVELCPLEE
   841  VWGYFEDALS HISRTKDYPE MEILWLMVKS WNTGVLMFSR SKYASAEKWC GLALRFLNHL
   901  TSFKESYETQ MNMLYSQLVE ALSNNKGPVF HEHGYWSKSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

pancreas: 56 nTPM
choroid plexus: 13 nTPM
testis: 11 nTPM
rectum: 1.4 nTPM
colon: 1.3 nTPM
spleen: 0.9 nTPM

Single-cell type

early primary spermatocytes: 182 nCPM
differentiating spermatogonia: 126 nCPM
pancreatic acinar cells: 47 nCPM
late spermatids: 46 nCPM
choroid plexus epithelial cells: 46 nCPM
late primary spermatocytes: 22 nCPM

Immune cell

T-reg: 0.3 nTPM
basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 8.5 nTPM
midbrain: 1 nTPM
cerebellum: 0.4 nTPM
cerebral cortex: 0.3 nTPM
hippocampal formation: 0.3 nTPM
medulla oblongata: 0.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TEX11.

Disease | AllUniProt

Conditions TEX11 is implicated in, by any mechanism.

Spermatogenic failure, X-linked, 2 (SPGFX2) MIM:309120

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 177 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Non-obstructive azoospermia
Male infertility
Spermatogenic failure, X-linked, 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.08
gnomAD pLI: 1
gnomAD missense Z: 1.81
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Meiosis specific protein Spo22/ZIP4/TEX11
Testis-expressed protein 11
Meiosis protein SPO22/ZIP4 like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEX11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX11 as an antibody target. Whether an autoantibody or antibody against TEX11 could matter depends on whether native TEX11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...