HYI

Protein identityUniProt · HPA

UniProt accession

Q5T013

Gene

HYI

Ensembl

ENSG00000178922

Chromosome

1

Canonical length

277 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

277 residues, UniProt reviewed canonical sequence.

>Q5T013|HYI
     1  MAPLRFSANL SWLFPELSGL PARVRAAGSS GFEAVEVAWP YAETPEALAR AAREAGLRLV
    61  LINTPPGDQE KGEMGLGAVP GRQAAFREGL EQAVRYAKAL GCPRIHLMAG RVPQGADRIA
   121  VKAEMEAVFL ENLRHAAGVL AQEDLVGLLE PINTRITDPQ YFLDTPQQAA AILQKVGRPN
   181  LQLQMDIFHW QIMDGNLTGN IREFLPIVGH VQVAQVPGRG EPSSPGELNF PYLFQLLEDE
   241  GYKGFVGCEY QPRGDTVEGL SWLRSYWDRR GHPEAGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HYI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

80 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.74

gnomAD pLI

0

gnomAD missense Z

-0.91

DepMap mean gene effect

-0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• glyoxylate metabolic process

Molecular functions

• hydroxypyruvate isomerase activity

Protein domainsUniProt · Pfam · InterPro

• Xylose isomerase-like, TIM barrel domain
• Hydroxypyruvate isomerase-like
• Xylose isomerase-like superfamily
• Sugar Epimerase/Isomerase
• Xylose isomerase-like TIM barrel

KeywordsUniProt

• Isomerase

InteractionsUniProt · HPA

Protein binding partners of HYI in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TEX11