Seroatlas · Human Serome Atlas

STMN2

Stathmin-2

Also known as: SCG10, SCGN10, STMN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q93045
Gene: STMN2
Ensembl: ENSG00000104435
Chromosome: 8
Canonical length: 179 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Vesicles

OverviewNCBI Gene

This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

179 residues, UniProt reviewed canonical sequence.

>Q93045|STMN2
     1  MAKTAMAYKE KMKELSMLSL ICSCFYPEPR NINIYTYDDM EVKQINKRAS GQAFELILKP
    61  PSPISEAPRT LASPKKKDLS LEEIQKKLEA AEERRKSQEA QVLKQLAEKR EHEREVLQKA
   121  LEENNNFSKM AEEKLILKME QIKENREANL AAIIERLQEK ERHAAEVRRN KELQVELSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STMN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 576 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 576 nTPM
cerebral cortex: 416 nTPM
hypothalamus: 415 nTPM
midbrain: 228 nTPM
hippocampal formation: 210 nTPM
amygdala: 203 nTPM

Single-cell type

other brain neurons: 560 nCPM
brain excitatory neurons: 367 nCPM
brain inhibitory neurons: 191 nCPM
pancreatic islet cells: 165 nCPM
retinal horizontal cells: 132 nCPM
retinal ganglion cells: 104 nCPM

Immune cell

plasmacytoid DC: 2.2 nTPM
NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 1,163 nTPM
hypothalamus: 804 nTPM
pons: 613 nTPM
medulla oblongata: 512 nTPM
white matter: 400 nTPM
cerebellum: 399 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 0.98
gnomAD missense Z: 1.69
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STMN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STMN2 as an antibody target. Whether an autoantibody or antibody against STMN2 could matter depends on whether native STMN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STMN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STMN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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