REDIC1

Protein identityUniProt · HPA

UniProt accession

Q86WS4

Gene

REDIC1

Ensembl

ENSG00000180116

Chromosome

12

Canonical length

652 aa

Protein class

Predicted intracellular proteins

Subcellular location

Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in meiotic cell cycle. Predicted to be located in chromosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

652 residues, UniProt reviewed canonical sequence.

>Q86WS4|REDIC1
     1  MNWVGGSRSR VLIKQERRKQ KEYFEKHRLK SKMKSLGVLS PVKNSAVSLD ILNLYMVNQI
    61  SCKKKIPETV RKPTHVNMNR DIKMPLRKHN LELTMSPHCV PSKLCLDDTE TNVNCQRLSS
   121  KEDLGPVQSQ GMDSYSMLHP QFSKIENCSF TPSSFSVELP SNRHISKLNF TSGIAPTPQK
   181  LAYEKKQNDQ RSTVNCSDSL LSKLNKSQDV FSPSHKTTRF GTLFERLNSL GNRNLLTKSP
   241  AVIMDEDCRS TDEIRQSDYI TEKHSIQHIW GKNGKEVSNF LEDVNQSTPN LLSENCDSFV
   301  SQNMINVLNI DEQRIKKTFN KCDYDSMGDT CVVTSSDKNH VTDRCIRNIF TVPELTFSNS
   361  TLNKTSYPEK CQPNKKYQRE YNKNERNDLS TSFENDYYPS SSERKEKFEN DYQEKTPQKS
   421  IQKYPANSMG NIPSEELHSK QSWDFGLDEI LMEEGGIYSL KSKRISTKKI SLDSAQSSRS
   481  TSYSPRPTDS CFSSSSDLPS EDEDQISQQI EDSNRMTIKT KEKMNNFYVE RMAKLSGDRI
   541  VKNDDKIHKQ NENFYQFSVK NNTDQFPQLQ CNSAHILQNK TNDNCVLQAA RCDAGIQTES
   601  ESVMEEKLDV AIQCDLISKC TCRSDVSLCN LERCSGNIKA DTTGGQEIHK NN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REDIC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.7

Highest tissue expression

8.2 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about REDIC1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 5 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Spermatogenic Failure

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• meiotic cell cycle

Molecular functions

• DNA binding
• RNA binding

Cellular components

• chromosome

Protein domainsUniProt · Pfam · InterPro

• Regulator of DNA class I crossover intermediates 1-like
• Regulator of DNA class I crossover intermediates 1-like

KeywordsUniProt

• Chromosome
• DNA-binding
• Meiosis
• RNA-binding

InteractionsUniProt · HPA

Protein binding partners of REDIC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MSH5
• TEX11