Seroatlas · Human Serome Atlas

SHOC1

Protein shortage in chiasmata 1 ortholog

Also known as: C9orf84, FLJ32779, MZIP2, SHOC1_HUMAN, Zip2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VXU9
Gene: SHOC1
Ensembl: ENSG00000165181
Chromosome: 9
Canonical length: 1444 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables ATP hydrolysis activity and single-stranded DNA binding activity. Predicted to be involved in resolution of meiotic recombination intermediates and synaptonemal complex assembly. Predicted to be located in chromosome. Predicted to be active in condensed nuclear chromosome. Implicated in spermatogenic failure 75. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1444 residues, UniProt reviewed canonical sequence.

>Q5VXU9|SHOC1
     1  MTDTSVLDQW KASFFVEDFL EKKTITRMVT QINCEFEEVV PSSNPDSQIE VEEVSLYTHM
    61  DYNEVFTPVS CLEKCSALQN QNQDLFIDDK GILFVSSRKH LPTLPTLLSR LKLFLVKDPL
   121  LDFKGQIFTE ANFSRECFSL QETLEAFVKE DFCMDKVNFC QEKLEDTICL NEPSSFLIEY
   181  EFLIPPSLKP EIDIPSLSEL KELLNPVPEI INYVDEKEKL FERDLTNKHG IEDIGDIKFS
   241  STEILTIQSQ SEPEECSKPG ELEMPLTPLF LTCQHSSVNS LRTELQTFPL SPVCKINLLT
   301  AEESANEYYM MWQLERCRSP LNPFLLTVPR IQEPHSQYSV TDLKKIFSVK EESLVINLEK
   361  AEWWKQAGLN LKMMETLEHL NTYLCHDNLS SNDTKIEIFL PTKVLQLESC LEHKSHSSPI
   421  ALIDEKSTNA HLSLPQKSPS LAKEVPDLCF SDDYFSDKGA AKEEKPKNDQ EPVNRIIQKK
   481  ENNDHFELDC TGPSIKSPSS SIIKKASFEH GKKQENDLDL LSDFIMLRNK YKTCTSKTEV
   541  TNSDEKHDKE ACSLTLQEES PIVHINKTLE EINQERGTDS VIEIQASDSQ CQAFCLLEAA
   601  ASPILKNLVS LCTLPTANWK FATVIFDQTR FLLKEQEKVV SDAVRQGTID EREMTFKHAA
   661  LLHLLVTIRD VLLTCSLDTA LGYLSKAKDI YNSILGPYLG DIWRQLEIVQ FIRGKKPETN
   721  YKIQELQCQI LSWMQSQQQI KVLIIIRMDS DGEKHFLIKI LNKIEGLTLT VLHSNERKDF
   781  LESEGVLRGT SSCVVVHNQY IGADFPWSNF SFVVEYNYVE DSCWTKHCKE LNIPYMAFKV
   841  ILPDTVLERS TLLDRFGGFL LEIQIPYVFF ASEGLLNTPD ILQLLESNYN ISLVERGCSE
   901  SLKLFGSSEC YVVVTIDEHT AIILQDLEEL NYEKASDNII MRLMALSLQY RYCWIILYTK
   961  ETLNSEYLLT EKTLHHLALI YAALVSFGLN SEELDVKLII APGVEATALI IRQIADHSLM
  1021  TSKRDPHEWL DKSWLKVSPS EEEMYLLDFP CINPLVAQLM LNKGPSLHWI LLATLCQLQE
  1081  LLPEVPEKVL KHFCSITSLF KIGSSSITKS PQISSPQENR NQISTLSSQS SASDLDSVIQ
  1141  EHNEYYQYLG LGETVQEDKT TILNDNSSIM ELKEISSFLP PVTSYNQTSY WKDSSCKSNI
  1201  GQNTPFLINI ESRRPAYNSF LNHSDSESDV FSLGLTQMNC ETIKSPTDTQ KRVSVVPRFI
  1261  NSQKRRTHEA KGFINKDVSD PIFSLEGTQS PLHWNFKKNI WEQENHPFNL QYGAQQTACN
  1321  KLYSQKGNLF TDQQKCLSDE SEGLTCESSK DETFWRELPS VPSLDLFRAS DSNANQKEFN
  1381  SLYFYQRAGK SLGQKRHHES SFNSGDKESL TGFMCSQLPQ FKKRRLAYEK VPGRVDGQTR
  1441  LRFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHOC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
adrenal gland: 3.6 nTPM
kidney: 1.3 nTPM
stomach: 1.1 nTPM
bone marrow: 0.4 nTPM
retina: 0.4 nTPM

Single-cell type

epicardial cells: 414 nCPM
renal collecting duct intercalated cells: 392 nCPM
adipocytes: 377 nCPM
sertoli cells: 373 nCPM
cardiomyocytes: 363 nCPM
fibro-adipogenic progenitors: 228 nCPM

Immune cell

neutrophil: 1.3 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 15 nTPM
white matter: 14 nTPM
medulla oblongata: 14 nTPM
hypothalamus: 13 nTPM
choroid plexus: 13 nTPM
thalamus: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SHOC1.

Disease | AllUniProt

Conditions SHOC1 is implicated in, by any mechanism.

Spermatogenic failure 75 (SPGF75) MIM:619949

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 50 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 75
Male infertility
Non-obstructive azoospermia
SHOC1-related condition

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein shortage in chiasmata 1 ortholog
Family of unknown function (DUF5587)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SHOC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHOC1 as an antibody target. Whether an autoantibody or antibody against SHOC1 could matter depends on whether native SHOC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHOC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHOC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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