Seroatlas · Human Serome Atlas

SETD7

Histone-lysine N-methyltransferase SETD7

Also known as: KIAA1717, KMT7, SET7, SET7/9, Set9, SETD7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WTS6
Gene: SETD7
Ensembl: ENSG00000145391
Chromosome: 4
Canonical length: 366 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Enables histone H3 methyltransferase activity; p53 binding activity; and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine dimethylation and peptidyl-lysine monomethylation. Acts upstream of or within DNA damage response and heterochromatin organization. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

366 residues, UniProt reviewed canonical sequence.

>Q8WTS6|SETD7
     1  MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE
    61  GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW
   121  IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP
   181  HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT
   241  VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT
   301  PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF
   361  QATQQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SETD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 100 nTPM
tongue: 69 nTPM
liver: 46 nTPM
adipose tissue: 42 nTPM
heart muscle: 38 nTPM
cervix: 38 nTPM

Single-cell type

prostatic glandular cells: 130 nCPM
hepatocytes: 98 nCPM
sertoli cells: 97 nCPM
fibro-adipogenic progenitors: 89 nCPM
retinal pigment epithelial cells: 77 nCPM
syncytiotrophoblasts: 75 nCPM

Immune cell

myeloid DC: 4.2 nTPM
classical monocyte: 3.9 nTPM
T-reg: 3.7 nTPM
non-classical monocyte: 3.1 nTPM
MAIT T-cell: 2.6 nTPM
intermediate monocyte: 1.9 nTPM

Brain region

white matter: 67 nTPM
medulla oblongata: 60 nTPM
spinal cord: 60 nTPM
thalamus: 59 nTPM
choroid plexus: 52 nTPM
midbrain: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 1.66
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

SET domain
MORN repeat
SET domain superfamily
SET domain
MORN repeat
Histone-lysine N-methyltransferase SETD7
SETD7, SET domain
Histone-lysine methyltransferase SETD7, N-terminal
Histone H3 K4-specific methyltransferase SET7 N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SETD7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SETD7 as an antibody target. Whether an autoantibody or antibody against SETD7 could matter depends on whether native SETD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SETD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SETD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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