Seroatlas · Human Serome Atlas

ZSWIM7

Zinc finger SWIM domain-containing protein 7

Also known as: SWS1, ZSWM7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q19AV6
Gene
ZSWIM7
Ensembl
ENSG00000214941
Chromosome
17
Canonical length
140 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Involved in double-strand break repair via homologous recombination and protein stabilization. Part of Shu complex. Implicated in ovarian dysgenesis 10 and spermatogenic failure 71. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>Q19AV6|ZSWIM7
     1  MAVVLPAVVE ELLSEMAAAV QESARIPDEY LLSLKFLFGS SATQALDLVD RQSITLISSP
    61  SGRRVYQVLG SSSKTYTCLA SCHYCSCPAF AFSVLRKSDS ILCKHLLAVY LSQVMRTCQQ
   121  LSVSDKQLTD ILLMEKKQEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSWIM7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 31 nTPM
  • midbrain: 17 nTPM
  • heart muscle: 17 nTPM
  • adrenal gland: 17 nTPM
  • choroid plexus: 17 nTPM
  • cerebral cortex: 16 nTPM

Single-cell type

  • cytotrophoblasts: 153 nCPM
  • platelets: 131 nCPM
  • early primary spermatocytes: 120 nCPM
  • megakaryocytes: 105 nCPM
  • syncytiotrophoblasts: 94 nCPM
  • ovarian stromal cells: 90 nCPM

Immune cell

  • myeloid DC: 42 nTPM
  • basophil: 28 nTPM
  • intermediate monocyte: 28 nTPM
  • classical monocyte: 27 nTPM
  • memory B-cell: 27 nTPM
  • plasmacytoid DC: 26 nTPM

Brain region

  • cerebral cortex: 11 nTPM
  • hypothalamus: 9.5 nTPM
  • pons: 9 nTPM
  • medulla oblongata: 8.7 nTPM
  • hippocampal formation: 8.6 nTPM
  • white matter: 8.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZSWIM7.

Disease | AllUniProt

Conditions ZSWIM7 is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 34 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0
gnomAD missense Z
0.33
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZSWIM7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSWIM7 as an antibody target. Whether an autoantibody or antibody against ZSWIM7 could matter depends on whether native ZSWIM7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSWIM7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSWIM7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZSWIM7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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