STAT transcription factor, N-terminal domain superfamily
IPR036535
Definition
The STAT protein (Signal Transducers and Activators of Transcription) family contains transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors, hence they act as signal transducers in the cytoplasm and transcription activators in the nucleus [[cite:PMID:12039028], [cite:PMID:26169829]]. The N-terminal domain of STAT is responsible for protein interactions. This domain has a multi-helical structure assembled into a hook-like structure PMID:9461439.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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