Seroatlas · Human Serome Atlas

SPOCD1

SPOC domain-containing protein 1

Also known as: FLJ25348, PPP1R146, SPOC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZMY3
Gene
SPOCD1
Ensembl
ENSG00000134668
Chromosome
1
Canonical length
1216 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a protein that belongs to the TFIIS family of transcription factors. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

1216 residues, UniProt reviewed canonical sequence.

>Q6ZMY3|SPOCD1
     1  MSQAGDVEGP STGDPVLSPQ HNCELLQNME GASSMPGLSP DGPGASSGPG VRAGSRRKIP
    61  RKEALRGGSS RAAGAAEVRP GVLELLAVVQ SRGSMLAPGL HMQLPSVPTQ GRALTSKRLQ
   121  VSLCDILDDS CPRKLCSRSA GLPERALACR ERLAGVEEVS CLRPREARDG GMSSPGCDRR
   181  SPTLSKEEPP GRPLTSSPDP VPVRVRKKWR RQGAHSECEE GAGDFLWLDQ SPRGDNLLSV
   241  GDPPQVADLE SLGGPCRPPS PKDTGSGPGE PGGSGAGCAS GTEKFGYLPA TGDGPQPGSP
   301  CGPVGFPVPS GGESLSSAAQ APPQSAALCL GASAQASAEQ QEAVCVVRTG SDEGQAPAQD
   361  QEELEAKAQP ASRGRLEQGL AAPADTCASS REPLGGLSSS LDTEASRACS GPFMEQRRSK
   421  GTKNLKKGPV PCAQDRGTDR SSDNSHQDRP EEPSPGGCPR LEEVKIPHGV KLVCYLGSGP
   481  VIQLLGAISH GQAGGQLPPK LEVLEDLMEV SSPSPAQRLR RKKRPMVQGP AGCQVFQPSP
   541  SGGTAGDPGG LSDPFYPPRS GSLALGDPSS DPACSQSGPM EAEEDSLPEQ PEDSAQLQQE
   601  KPSLYIGVRG TVVRSMQEVL WTRLRELPDP VLSEEVVEGI AAGIEAALWD LTQGTNGRYK
   661  TKYRSLLFNL RDPRNLDLFL KVVHGDVTPY DLVRMSSMQL APQELARWRD QEEKRGLNII
   721  EQQQKEPCRL PASKMTHKGE VEIQRDMDQT LTLEDLVGPQ MFMDCSPQAL PIASEDTTGQ
   781  HDHHFLDPNC HICKDWEPSN ELLGSFEAAK SCGDNIFQKA LSQTPMPAPE MPKTRELSPT
   841  EPQDRVPPSG LHVPAAPTKA LPCLPPWEGV LDMFSIKRFR ARAQLVSGHS CRLVQALPTV
   901  IRSAGCIPSN IVWDLLASIC PAKAKDVCVV RLCPHGARDT QNCRLLYSYL NDRQRHGLAS
   961  VEHMGMVLLP LPAFQPLPTR LRPLGGPGLW ALPVSPLLSP GLEVTHSSLL LAVLLPKEGL
  1021  PDTAGSSPWL GKVQKMVSFN SKVEKRYYQP DDRRPNVPLK GTPPPGGAWQ QSQGRGSIAP
  1081  RGISAWQRPP RGRGRLWPEP ENWQHPGRGQ WPPEPGLRQS QHPYSVAPAG HGFGRGQHFH
  1141  RDSCPHQALL RHLESLATMS HQLQALLCPQ TKSSIPRPLQ RLSSALAAPE PPGPARDSSL
  1201  GPTDEAGSEC PFPRKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPOCD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 11 nTPM
  • testis: 9.4 nTPM
  • urinary bladder: 8.9 nTPM
  • lung: 7.1 nTPM
  • adipose tissue: 3 nTPM
  • appendix: 2.9 nTPM

Single-cell type

  • platelets: 185 nCPM
  • urothelial cells: 158 nCPM
  • decidual stromal cells: 30 nCPM
  • undifferentiated spermatogonia: 27 nCPM
  • sertoli cells: 17 nCPM
  • megakaryocytes: 12 nCPM

Immune cell

  • total PBMC: 3.1 nTPM
  • neutrophil: 0.9 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • thalamus: 24 nTPM
  • medulla oblongata: 14 nTPM
  • pons: 7.5 nTPM
  • cerebral cortex: 7.4 nTPM
  • white matter: 5.5 nTPM
  • choroid plexus: 3.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPOCD1.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 192 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Male infertility with azoospermia or oligozoospermia due to single gene mutation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
1.02
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPOCD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPOCD1 as an antibody target. Whether an autoantibody or antibody against SPOCD1 could matter depends on whether native SPOCD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPOCD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPOCD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPOCD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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