Seroatlas · Human Serome Atlas

KIAA0408

Uncharacterized protein KIAA0408

Also known as: K0408_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZU52
Gene
KIAA0408
Ensembl
ENSG00000189367
Chromosome
6
Canonical length
694 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for KIAA0408 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

694 residues, UniProt reviewed canonical sequence.

>Q6ZU52|KIAA0408
     1  MDLHKQWENT ETNWHKEKME LLDQFDNERK EWESQWKIMQ KKIEELCREV KLWRKININE
    61  SAKIIDLYHE KTIPEKVIES SPNYPDLGQS EFIRTNHKDG LRKENKREQS LVSGGNQMCK
   121  EQKATKKSKV GFLDPLATDN QKECEAWPDL RTSEEDSKSC SGALSTALEE LAKVSEELCS
   181  FQEEIRKRSN HRRMKSDSFL QEMPNVTNIP HGDPMINNDQ CILPISLEKE KQKNRKNLSC
   241  TNVLQSNSTK KCGIDTIDLK RNETPPVPPP RSTSRNFPSS DSEQAYERWK ERLDHNSWVP
   301  HEGRSKRNYN PHFPLRQQEM SMLYPNEGKT SKDGIIFSSL VPEVKIDSKP PSNEDVGLSM
   361  WSCDIGIGAK RSPSTSWFQK TCSTPSNPKY EMVIPDHPAK SHPDLHVSND CSSSVAESSS
   421  PLRNFSCGFE RTTRNEKLAA KTDEFNRTVF RTDRNCQAIQ QNHSCSKSSE DLKPCDTSST
   481  HTGSISQSND VSGIWKTNAH MPVPMENVPD NPTKKSTTGL VRQMQGHLSP RSYRNMLHEH
   541  DWRPSNLSGR PRSADPRSNY GVVEKLLKTY ETATESALQN SKCFQDNWTK CNSDVSGGAT
   601  LSQHLEMLQM EQQFQQKTAV WGGQEVKQGI DPKKITEESM SVNASHGKGF SRPARPANRR
   661  LPSRWASRSP SAPPALRRTT HNYTISLRSE ALMV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA0408 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 26 nTPM
  • cerebellum: 22 nTPM
  • spinal cord: 19 nTPM
  • cerebral cortex: 19 nTPM
  • adipose tissue: 16 nTPM
  • midbrain: 15 nTPM

Single-cell type

  • brain excitatory neurons: 45 nCPM
  • brain inhibitory neurons: 43 nCPM
  • other brain neurons: 40 nCPM
  • bergmann glia: 29 nCPM
  • oligodendrocyte progenitor cells: 25 nCPM
  • myosatellite cells: 18 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 30 nTPM
  • cerebral cortex: 27 nTPM
  • white matter: 26 nTPM
  • basal ganglia: 24 nTPM
  • spinal cord: 24 nTPM
  • hypothalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
0.08
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIAA0408 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA0408 as an antibody target. Whether an autoantibody or antibody against KIAA0408 could matter depends on whether native KIAA0408 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA0408 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA0408 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KIAA0408. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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