Seroatlas · Human Serome Atlas

MON2

Protein MON2 homolog

Also known as: KIAA1040, MON2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3U7
Gene: MON2
Ensembl: ENSG00000061987
Chromosome: 12
Canonical length: 1717 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center
Quaternary structure: Homooligomer

OverviewNCBI Gene

Predicted to enable proton transmembrane transporter activity. Predicted to be involved in Golgi to endosome transport. Located in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1717 residues, UniProt reviewed canonical sequence.

>Q7Z3U7|MON2
     1  MSGTSSPEAV KKLLENMQSD LRALSLECKK KFPPVKEAAE SGIIKVKTIA ARNTEILAAL
    61  KENSSEVVQP FLMGCGTKEP KITQLCLAAI QRLMSHEVVS ETAAGNIINM LWQLMENSLE
   121  ELKLLQTVLV LLTTNTVVHD EALSKAIVLC FRLHFTKDNI TNNTAAATVR QVVTVVFERM
   181  VAEDERHRDI IEQPVLVQGN SNRRSVSTLK PCAKDAYMLF QDLCQLVNAD APYWLVGMTE
   241  MTRTFGLELL ESVLNDFPQV FLQHQEFSFL LKERVCPLVI KLFSPNIKFR QGSSTSSSPA
   301  PVEKPYFPIC MRLLRVVSVL IKQFYSLLVT ECEIFLSLLV KFLDADKPQW LRAVAVESIH
   361  RFCVQPQLLR SFCQSYDMKQ HSTKVFRDIV NALGSFIQSL FLVPPTGNPA TSNQAGNNNL
   421  GGSVSAPANS GMVGIGGGVT LLPAFEYRGT WIPILTITVQ GSAKATYLEM LDKVEPPTIP
   481  EGYAMSVAFH CLLDLVRGIT SMIEGELGEL ETECQTTTEE GSSPTQSTEQ QDLQSTSDQM
   541  DKEIVSRAVW EEMVNACWCG LLAALSLLLD ASTDEAATEN ILKAELTMAA LCGRLGLVTS
   601  RDAFITAICK GSLPPHYALT VLNTTTAATL SNKSYSVQGQ SVMMISPSSE SHQQVVAVGQ
   661  PLAVQPQGTV MLTSKNIQCM RTLLNLAHCH GAVLGTSWQL VLATLQHLVW ILGLKPSSGG
   721  ALKPGRAVEG PSTVLTTAVM TDLPVISNIL SRLFESSQYL DDVSLHHLIN ALCSLSLEAM
   781  DMAYGNNKEP SLFAVAKLLE TGLVNMHRIE ILWRPLTGHL LEVCQHPNSR MREWGAEALT
   841  SLIKAGLTFN HDPPLSQNQR LQLLLLNPLK EMSNINHPDI RLKQLECVLQ ILQSQGDSLG
   901  PGWPLVLGVM GAIRNDQGES LIRTAFQCLQ LVVTDFLPTM PCTCLQIVVD VAGSFGLHNQ
   961  ELNISLTSIG LLWNISDYFF QRGETIEKEL NKEEAAQQKQ AEEKGVVLNR PFHPAPPFDC
  1021  LWLCLYAKLG ELCVDPRPAV RKSAGQTLFS TIGAHGTLLQ HSTWHTVIWK VLFHLLDRVR
  1081  ESSTTADKEK IESGGGNILI HHSRDTAEKQ WAETWVLTLA GVARIFNTRR YLLQPLGDFS
  1141  RAWDVLLDHI QSAALSKNNE VSLAALKSFQ EILQIVSPVR DSDKPETPPV VNVPVPVLIG
  1201  PISGMSRPFV RTDSIGEKLG RYSSSEPPIV TDELEDLNLW WAAWNTWYRI GSESTKPPIT
  1261  FDKLTFIPSQ PFLTALIQIF PALYQHIKTG FNMDDLQKLG VILHSAISVP ISSDASPFIL
  1321  PSYTEAVLTS LQEAVLTALD VLQKAICVGP ENMQIMYPAI FDQLLAFVEF SCKPPQYGQL
  1381  ETKHIANAKY NQIQLFAPAE WVALNYVPFA ERSLEVVVDL YQKTACHKAV VNEKVLQNII
  1441  KTLRVPLSLK YSCPSESTWK LAVSSLLRVL SIGLPVARQH ASSGKFDSMW PELANTFEDF
  1501  LFTKSIPPDN LSIQEFQRNE NIDVEVVQLI SNEILPYANF IPKEFVGQIM TMLNKGSIHS
  1561  QSSSFTEAEI DIRLREEFSK MCFETLLQFS FSNKVTTPQE GYISRMALSV LLKRSQDVLH
  1621  RYIEDERLSG KCPLPRQQVT EIIFVLKAVS TLIDSLKKTQ PENVDGNTWA QVIALYPTLV
  1681  ECITCSSSEV CSALKEALVP FKDFMQPPAS RVQNGES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MON2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

retina: 16 nTPM
parathyroid gland: 15 nTPM
liver: 13 nTPM
pancreas: 13 nTPM
thyroid gland: 12 nTPM
thymus: 12 nTPM

Single-cell type

somatotrophs: 479 nCPM
lactotrophs: 459 nCPM
pituicytes/fscs: 368 nCPM
corticotrophs: 341 nCPM
neutrophil progenitors: 339 nCPM
oligodendrocytes: 339 nCPM

Immune cell

neutrophil: 4.4 nTPM
memory CD8 T-cell: 3.4 nTPM
eosinophil: 3.2 nTPM
MAIT T-cell: 3.2 nTPM
naive CD8 T-cell: 3.2 nTPM
intermediate monocyte: 3.1 nTPM

Brain region

white matter: 60 nTPM
basal ganglia: 41 nTPM
choroid plexus: 41 nTPM
medulla oblongata: 41 nTPM
cerebellum: 38 nTPM
pons: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.59
gnomAD missense Z: 3.2
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Mon2/Sec7/BIG1-like, HDS
Armadillo-type fold
Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain
Mon2/Sec7/BIG1-like, HUS domain
Mon2/Sec7/BIG1-like, HDS
Mon2/Sec7/BIG1-like, HUS domain
Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain
Mon2, C-terminal
C-terminal region of Mon2 protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MON2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SNX3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MON2 as an antibody target. Whether an autoantibody or antibody against MON2 could matter depends on whether native MON2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MON2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MON2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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