Seroatlas · Human Serome Atlas

SH2D2A

SH2 domain-containing protein 2A

Also known as: F2771, SH22A_HUMAN, TSAd

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NP31
Gene: SH2D2A
Ensembl: ENSG00000027869
Chromosome: 1
Canonical length: 389 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q9NP31|SH2D2A
     1  MEFPLAQICP QGSHEAPIPT FSTFQITDMT RRSCQNLGYT AASPQAPEAA SNTGNAERAE
    61  EVPGEGSLFL QAETRAWFQK TQAHWLLQHG AAPAWFHGFI TRREAERLLE PKPQGCYLVR
   121  FSESAVTFVL TYRSRTCCRH FLLAQLRDGR HVVLGEDSAH ARLQDLLLHY TAHPLSPYGE
   181  TLTEPLARQT PEPAGLSLRT EESNFGSKSQ DPNPQYSPII KQGQAPVPMQ KEGAGEKEPS
   241  QLLRPKPPIP AKPQLPPEVY TIPVPRHRPA PRPKPSNPIY NEPDEPIAFY AMGRGSPGEA
   301  PSNIYVEVED EGLPATLGHP VLRKSWSRPV PGGQNTGGSQ LHSENSVIGQ GPPLPHQPPP
   361  AWRHTLPHNL SRQVLQDRGQ AWLPLGPPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH2D2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

thymus: 14 nTPM
spleen: 13 nTPM
appendix: 11 nTPM
lymph node: 8.8 nTPM
choroid plexus: 6.2 nTPM
tonsil: 5.5 nTPM

Single-cell type

nk-cells: 125 nCPM
t-cells: 79 nCPM
decidual stromal cells: 26 nCPM
retinal bipolar cells: 24 nCPM
innate lymphoid cells: 17 nCPM
platelets: 9.8 nCPM

Immune cell

gdT-cell: 67 nTPM
MAIT T-cell: 62 nTPM
memory CD8 T-cell: 41 nTPM
T-reg: 34 nTPM
NK-cell: 29 nTPM
memory CD4 T-cell: 28 nTPM

Brain region

cerebellum: 6.9 nTPM
medulla oblongata: 2.8 nTPM
choroid plexus: 2.7 nTPM
pons: 2.1 nTPM
hypothalamus: 2 nTPM
white matter: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SH3 domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH2D2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH2D2A as an antibody target. Whether an autoantibody or antibody against SH2D2A could matter depends on whether native SH2D2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH2D2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH2D2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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