Seroatlas · Human Serome Atlas

TENT5B

Terminal nucleotidyltransferase 5B

Also known as: FAM46B, MGC16491, TET5B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96A09
Gene
TENT5B
Ensembl
ENSG00000158246
Chromosome
1
Canonical length
425 aa
Protein class
Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Enables poly(A) RNA polymerase activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of cell population proliferation; and positive regulation of translation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q96A09|TENT5B
     1  MMPSESGAER RDRAAAQVGT AAATAVATAA PAGGGPDPEA LSAFPGRHLS GLSWPQVKRL
    61  DALLSEPIPI HGRGNFPTLS VQPRQIVQVV RSTLEEQGLH VHSVRLHGSA ASHVLHPESG
   121  LGYKDLDLVF RVDLRSEASF QLTKAVVLAC LLDFLPAGVS RAKITPLTLK EAYVQKLVKV
   181  CTDSDRWSLI SLSNKSGKNV ELKFVDSVRR QFEFSIDSFQ IILDSLLLFG QCSSTPMSEA
   241  FHPTVTGESL YGDFTEALEH LRHRVIATRS PEEIRGGGLL KYCHLLVRGF RPRPSTDVRA
   301  LQRYMCSRFF IDFPDLVEQR RTLERYLEAH FGGADAARRY ACLVTLHRVV NESTVCLMNH
   361  ERRQTLDLIA ALALQALAEQ GPAATAALAW RPPGTDGVVP ATVNYYVTPV QPLLAHAYPT
   421  WLPCN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TENT5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
116 nTPM

Expression across tissuesHPA

Tissue

  • skin: 116 nTPM
  • esophagus: 108 nTPM
  • blood vessel: 71 nTPM
  • vagina: 44 nTPM
  • colon: 43 nTPM
  • urinary bladder: 36 nTPM

Single-cell type

  • esophageal apical cells: 380 nCPM
  • esophageal suprabasal cells: 262 nCPM
  • suprabasal keratinocytes: 193 nCPM
  • alveolar cells type 1: 117 nCPM
  • basal keratinocytes: 100 nCPM
  • esophageal basal cells: 79 nCPM

Immune cell

  • intermediate monocyte: 0.4 nTPM
  • eosinophil: 0.2 nTPM
  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • medulla oblongata: 4.2 nTPM
  • cerebellum: 3.1 nTPM
  • pons: 2.9 nTPM
  • cerebral cortex: 1.9 nTPM
  • hypothalamus: 1.8 nTPM
  • choroid plexus: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.18
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TENT5B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TENT5B as an antibody target. Whether an autoantibody or antibody against TENT5B could matter depends on whether native TENT5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TENT5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TENT5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TENT5B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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