Seroatlas · Human Serome Atlas

LASP1

LIM and SH3 domain protein 1

Also known as: Lasp-1, LASP1_HUMAN, MLN50

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14847
Gene
LASP1
Ensembl
ENSG00000002834
Chromosome
17
Canonical length
261 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Focal adhesion sites,Cytosol

OverviewNCBI Gene

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q14847|LASP1
     1  MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ
    61  SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI
   121  KYHEEFEKSR MGPSGGEGME PERRDSQDGS SYRRPLEQQQ PHHIPTSAPV YQQPQQQPVA
   181  QSYGGYKEPA APVSIQRSAP GGGGKRYRAV YDYSAADEDE VSFQDGDTIV NVQQIDDGWM
   241  YGTVERTGDT GMLPANYVEA I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LASP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
159 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 159 nTPM
  • duodenum: 124 nTPM
  • bone marrow: 119 nTPM
  • stomach: 91 nTPM
  • colon: 87 nTPM
  • rectum: 87 nTPM

Single-cell type

  • late spermatids: 1,082 nCPM
  • neutrophils: 421 nCPM
  • enterocytes: 344 nCPM
  • hepatic stellate cells: 297 nCPM
  • foveolar cells: 291 nCPM
  • neutrophil progenitors: 253 nCPM

Immune cell

  • neutrophil: 67 nTPM
  • non-classical monocyte: 42 nTPM
  • eosinophil: 35 nTPM
  • NK-cell: 34 nTPM
  • intermediate monocyte: 33 nTPM
  • total PBMC: 33 nTPM

Brain region

  • thalamus: 110 nTPM
  • midbrain: 101 nTPM
  • hypothalamus: 94 nTPM
  • amygdala: 94 nTPM
  • pons: 91 nTPM
  • medulla oblongata: 84 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.98
gnomAD missense Z
2.21
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LASP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LASP1 as an antibody target. Whether an autoantibody or antibody against LASP1 could matter depends on whether native LASP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LASP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LASP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LASP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...