Seroatlas · Human Serome Atlas

ADGB

Androglobin

Also known as: ADGB_HUMAN, C6orf103, CAPN16, dJ408K24.1, FLJ23121

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7X0
Gene: ADGB
Ensembl: ENSG00000118492
Chromosome: 6
Canonical length: 1667 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Mid piece

OverviewNCBI Gene

Predicted to enable several functions, including calcium-dependent cysteine-type endopeptidase activity; heme binding activity; and oxygen binding activity. Predicted to be involved in spermatid development. Predicted to be located in sperm flagellum. Predicted to be active in sperm annulus and sperm midpiece. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1667 residues, UniProt reviewed canonical sequence.

>Q8N7X0|ADGB
     1  MASKQTKKKE VHRINSAHGS DKSKDFYPFG SNVQSGSTEQ KKGKFPLWPE WSEADINSEK
    61  WDAGKGAKEK DKTGKSPVFH FFEDPEGKIE LPPSLKIYSW KRPQDILFSQ TPVVVKNEIT
   121  FDLFSANEHL LCSELMRWII SEIYAVWKIF NGGILSNYFK GTSGEPPLLP WKPWEHIYSL
   181  CKAVKGHMPL FNSYGKYVVK LYWMGCWRKI TIDDFLPFDE DNNLLLPATT YEFELWPMLL
   241  SKAIIKLANI DIHVADRREL GEFTVIHALT GWLPEVISLH PGYMDKVWEL LKEILPEFKL
   301  SDEASSESKI AVLDSKLKEP GKEGKEGKEI KDGKEVKDVK EFKPESSLTT LKAPEKSDKV
   361  PKEKADARDI GKKRSKDGEK EKFKFSLHGS RPSSEVQYSV QSLSDCSSAI QTSHMVVYAT
   421  FTPLYLFENK IFSLEKMADS AEKLREYGLS HICSHPVLVT RSRSCPLVAP PKPPPLPPWK
   481  LIRQKKETVI TDEAQELIVK KPERFLEISS PFLNYRMTPF TIPTEMHFVR SLIKKGIPPG
   541  SDLPSVSETD ETATHSQTDL SQITKATSQG NTASQVILGK GTDEQTDFGL GDAHQSDGLN
   601  LEREIVSQTT ATQEKSQEEL PTTNNSVSKE IWLDFEDFCV CFQNIYIFHK PSSYCLNFQK
   661  SEFKFSEERV SYYLFVDSLK PIELLVCFSA LVRWGEYGAL TKDSPPIEPG LLTAETFSWK
   721  SLKPGSLVLK IHTYATKATV VRLPVGRHML LFNAYSPVGH SIHICSMVSF VIGDEHVVLP
   781  NFEPESCRFT EQSLLIMKAI GNVIANFKDK GKLSAALKDL QTAHYPVPFH DKELTAQHFR
   841  VFHLSLWRLM KKVQITKPPP NFKFAFRAMV LDLELLNSSL EEVSLVEWLD VKYCMPTSDK
   901  EYSAEEVAAA IKIQAMWRGT YVRLLMKARI PDTKENISVA DTLQKVWAVL EMNLEQYAVS
   961  LLRLMFKSKC KSLESYPCYQ DEETKIAFAD YTVTYQEQPP NSWFIVFRET FLVHQDMILV
  1021  PKVYTTLPIC ILHIVNNDTM EQVPKVFQKV VPYLYTKNKK GYTFVAEAFT GDTYVAASRW
  1081  KLRLIGSSAP LPCLSRDSPC NSFAIKEIRD YYIPNDKKIL FRYSVKVLTP QPATIQVRTS
  1141  KPDAFIKLQV LENEETMVSS TGKGQAIIPA FHFLKSEKGL SSQSSKHILS FHSASKKEQE
  1201  VYVKKKAAQG IQKSPKGRAV SAIQDIGLPL VEEETTSTPT REDSSSTPLQ NYKYIIQCSV
  1261  LYNSWPLTES QLTFVQALKD LKKSNTKAYG ERHEELINLG SPDSHTISEG QKSSVTSKTT
  1321  RKGKEKSSEK EKTAKEKQAP RFEPQISTVH PQQEDPNKPY WILRLVTEHN ESELFEVKKD
  1381  TERADEIRAM KQAWETTEPG RAIKASQARL HYLSGFIKKT SDAESPPISE SQTKPKEEVE
  1441  TAARGVKEPN SKNSAGSESK EMTQTGSGSA VWKKWQLTKG LRDVAKSTSS ESGGVSSPGK
  1501  EEREQSTRKE NIQTGPRTRS PTILETSPRL IRKALEFMDL SQYVRKTDTD PLLQTDELNQ
  1561  QQAMQKAEEI HQFRQHRTRV LSIRNIDQEE RLKLKDEVLD MYKEMQDSLD EARQKIFDIR
  1621  EEYRNKLLEA EHLKLETLAA QEAAMKLETE KMTPAPDTQK KKKGKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
fallopian tube: 7.1 nTPM
choroid plexus: 4.7 nTPM
hypothalamus: 1.6 nTPM
lung: 1.5 nTPM
hippocampal formation: 1.4 nTPM

Single-cell type

ependymal cells: 1,253 nCPM
respiratory ciliated cells: 691 nCPM
early spermatids: 366 nCPM
late primary spermatocytes: 357 nCPM
fallopian tube ciliated cells: 344 nCPM
choroid plexus epithelial cells: 300 nCPM

Immune cell

myeloid DC: 0.4 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 13 nTPM
medulla oblongata: 12 nTPM
midbrain: 7.9 nTPM
spinal cord: 6.4 nTPM
pons: 3.1 nTPM
white matter: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: 0.59

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Peptidase C2, calpain, catalytic domain
Globin/Protoglobin
Papain-like cysteine peptidase superfamily
Calpain family cysteine protease
Androglobin-like
Androglobin, domain II
Androglobin, domain IV
Androglobin, domain V
Androglobin, circularly permuted globin domain
Androglobin, domain II
Androglobin, domain IV
Androglobin, domain V

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADGB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGB as an antibody target. Whether an autoantibody or antibody against ADGB could matter depends on whether native ADGB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADGB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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