Seroatlas · Human Serome Atlas

PODXL2

Podocalyxin-like protein 2

Also known as: endoglycan, PDXL2_HUMAN, PODLX2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZ53
Gene: PODXL2
Ensembl: ENSG00000114631
Chromosome: 3
Canonical length: 605 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

605 residues, UniProt reviewed canonical sequence.

>Q9NZ53|PODXL2
     1  MGRLLRAARL PPLLSPLLLL LVGGAFLGAC VAGSDEPGPE GLTSTSLLDL LLPTGLEPLD
    61  SEEPSETMGL GAGLGAPGSG FPSEENEESR ILQPPQYFWE EEEELNDSSL DLGPTADYVF
   121  PDLTEKAGSI EDTSQAQELP NLPSPLPKMN LVEPPWHMPP REEEEEEEEE EEREKEEVEK
   181  QEEEEEEELL PVNGSQEEAK PQVRDFSLTS SSQTPGATKS RHEDSGDQAS SGVEVESSMG
   241  PSLLLPSVTP TTVTPGDQDS TSQEAEATVL PAAGLGVEFE APQEASEEAT AGAAGLSGQH
   301  EEVPALPSFP QTTAPSGAEH PDEDPLGSRT SASSPLAPGD MELTPSSATL GQEDLNQQLL
   361  EGQAAEAQSR IPWDSTQVIC KDWSNLAGKN YIILNMTENI DCEVFRQHRG PQLLALVEEV
   421  LPRHGSGHHG AWHISLSKPS EKEQHLLMTL VGEQGVVPTQ DVLSMLGDIR RSLEEIGIQN
   481  YSTTSSCQAR ASQVRSDYGT LFVVLVVIGA ICIIIIALGL LYNCWQRRLP KLKHVSHGEE
   541  LRFVENGCHD NPTLDVASDS QSEMQEKHPS LNGGGALNGP GSWGALMGGK RDPEDSDVFE
   601  EDTHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PODXL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 99 nTPM
cerebellum: 82 nTPM
cerebral cortex: 68 nTPM
hippocampal formation: 61 nTPM
pituitary gland: 56 nTPM
midbrain: 54 nTPM

Single-cell type

late spermatids: 267 nCPM
undifferentiated spermatogonia: 122 nCPM
other brain neurons: 98 nCPM
brain inhibitory neurons: 73 nCPM
differentiating spermatogonia: 70 nCPM
late primary spermatocytes: 68 nCPM

Immune cell

memory CD4 T-cell: 0.6 nTPM
plasmacytoid DC: 0.6 nTPM
T-reg: 0.5 nTPM
MAIT T-cell: 0.3 nTPM
memory B-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM

Brain region

hypothalamus: 142 nTPM
pons: 121 nTPM
midbrain: 112 nTPM
cerebral cortex: 101 nTPM
medulla oblongata: 101 nTPM
basal ganglia: 97 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 0.91
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

leukocyte tethering or rolling

Molecular functions

glycosaminoglycan binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

CD34/Podocalyxin
CD34/Podocalyxin family
Podocalyxin-like protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PODXL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PODXL2 as an antibody target. Whether an autoantibody or antibody against PODXL2 could matter depends on whether native PODXL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PODXL2 is annotated at the cell surface, where native PODXL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PODXL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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