Seroatlas · Human Serome Atlas

SCHIP1

Schwannomin-interacting protein 1

Also known as: SCHI1_HUMAN, SCHIP-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DPB3
Gene: SCHIP1
Ensembl: ENSG00000151967
Chromosome: 3
Canonical length: 487 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Plasma membrane,Cell Junctions,Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in positive regulation of hippo signaling. Predicted to act upstream of or within several processes, including face morphogenesis; fibroblast migration; and luteinization. Located in several cellular components, including cell junction; cytosol; and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>P0DPB3|SCHIP1
     1  MERSGQRVTT WDCDQGKHSD SDYREDGMDL GSDAGSSSSS SRASSQSNST KVTPCSECKS
    61  SSSPGGSLDL VSALEDYEEP FPVYQKKVID EWAPEEDGEE EEEEDERDQR GYRDDRSPAR
   121  EPGDVSARTR SGGGGGRSAT TAMPPPVPNG NLHQHDPQDL RHNGNVVVAG RPSCSRGPRR
   181  AIQKPQPAGG RRSGRGPAAG GLCLQPPDGG TCVPEEPPVP PMDWEALEKH LAGLQFREQE
   241  VRNQGQARTN STSAQKNERE SIRQKLALGS FFDDGPGIYT SCSKSGKPSL SSRLQSGMNL
   301  QICFVNDSGS DKDSDADDSK TETSLDTPLS PMSKQSSSYS DRDTTEEESE SLDDMDFLTR
   361  QKKLQAEAKM ALAMAKPMAK MQVEVEKQNR KKSPVADLLP HMPHISECLM KRSLKPTDLR
   421  DMTIGQLQVI VNDLHSQIES LNEELVQLLL IRDELHTEQD AMLVDIEDLT RHAESQQKHM
   481  AEKMPAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCHIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 93 nTPM
tongue: 86 nTPM
spinal cord: 77 nTPM
amygdala: 76 nTPM
cerebral cortex: 75 nTPM
heart muscle: 75 nTPM

Single-cell type

oligodendrocytes: 317 nCPM
brain excitatory neurons: 117 nCPM
ependymal cells: 103 nCPM
oligodendrocyte progenitor cells: 97 nCPM
astrocytes: 74 nCPM
bergmann glia: 67 nCPM

Immune cell

plasmacytoid DC: 6.9 nTPM
basophil: 2.1 nTPM
myeloid DC: 1.5 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 99 nTPM
spinal cord: 57 nTPM
basal ganglia: 53 nTPM
hippocampal formation: 49 nTPM
medulla oblongata: 49 nTPM
hypothalamus: 48 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SCHIP1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 2 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Familial meningioma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 0.99
gnomAD missense Z: 1.9
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of hippo signaling

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCHIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCHIP1 as an antibody target. Whether an autoantibody or antibody against SCHIP1 could matter depends on whether native SCHIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCHIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCHIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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