Seroatlas · Human Serome Atlas

S100PBP

S100P-binding protein

Also known as: FLJ12903, S100PBPR, S1PBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96BU1
Gene
S100PBP
Ensembl
ENSG00000116497
Chromosome
1
Canonical length
408 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

This gene encodes a protein that was originally identified by its interaction with S100 calcium-binding protein P. Expression of this protein has been reported to be associated with pancreatic ductal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

408 residues, UniProt reviewed canonical sequence.

>Q96BU1|S100PBP
     1  MMCSRVPSEQ SSGTSLLPKD GAPFSWDSLD EDGLDDSLLE LSEGEEDDGD VNYTEEEIDA
    61  LLKEDDPSYE QSSGEDDGGH VEKGERGSQI LLDTPREKNS SYSLGPVAET PDLFKLPQLS
   121  TSSGHGPAHT KPLNRRSVLE KNLIKVTVAP FNPTVCDALL DKDETDSSKD TEKLSSLGEE
   181  MREDGLSPNE SKLCTESEGI SPNNSAWNGP QLSSSNNNFQ QTVSDKNMPD SENPTSVFSR
   241  ISDHSETPNM ELSCRNGGSH KSSCEMRSLV VSTSSNKQDV LNKDSGKMKG HERRLGKVIP
   301  VLQTKTRTNV PTFSQSNLEQ QKQLYLRSVI AHIEDPEDTN QGISGELCAL MDQVHHMQHS
   361  KWQHPSDLTT RNYARRQKHL QRYSLTQWVD RNMRSHHRFQ RLPDFSYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against S100PBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • testis: 31 nTPM
  • thymus: 17 nTPM
  • ovary: 17 nTPM
  • cerebellum: 17 nTPM
  • spleen: 15 nTPM
  • lymph node: 15 nTPM

Single-cell type

  • early primary spermatocytes: 211 nCPM
  • thymocytes: 166 nCPM
  • sertoli cells: 147 nCPM
  • nk-cells: 108 nCPM
  • adrenal medulla cells: 106 nCPM
  • cone photoreceptor cells: 97 nCPM

Immune cell

  • NK-cell: 19 nTPM
  • plasmacytoid DC: 11 nTPM
  • memory B-cell: 8.2 nTPM
  • MAIT T-cell: 7.9 nTPM
  • basophil: 7.4 nTPM
  • memory CD8 T-cell: 7 nTPM

Brain region

  • basal ganglia: 35 nTPM
  • white matter: 31 nTPM
  • hypothalamus: 29 nTPM
  • medulla oblongata: 26 nTPM
  • midbrain: 26 nTPM
  • thalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.95
gnomAD missense Z
0.08
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • S100P-binding protein
  • S100P-binding protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of S100PBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads S100PBP as an antibody target. Whether an autoantibody or antibody against S100PBP could matter depends on whether native S100PBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

S100PBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label S100PBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/S100PBP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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