Seroatlas · Human Serome Atlas

CTNNAL1

Alpha-catulin

Also known as: alpha-CATU, CLLP, CTNL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBT7
Gene
CTNNAL1
Ensembl
ENSG00000119326
Chromosome
9
Canonical length
734 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable actin filament binding activity and cadherin binding activity. Acts upstream of or within Rho protein signal transduction. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

734 residues, UniProt reviewed canonical sequence.

>Q9UBT7|CTNNAL1
     1  MAASPGPAGV GGAGAVYGSG SSGFALDSGL EIKTRSVEQT LLPLVSQITT LINHKDNTKK
    61  SDKTLQAIQR VGQAVNLAVG RFVKVGEAIA NENWDLKEEI NIACIEAKQA GETIAALTDI
   121  TNLNHLESDG QITIFTDKTG VIKAARLLLS SVTKVLLLAD RVVIKQIITS RNKVLATMER
   181  LEKVNSFQEF VQIFSQFGNE MVEFAHLSGD RQNDLKDEKK KAKMAAARAV LEKCTMMLLT
   241  ASKTCLRHPN CESAHKNKEG VFDRMKVALD KVIEIVTDCK PNGETDISSI SIFTGIKEFK
   301  MNIEALRENL YFQSKENLSV TLEVILERME DFTDSAYTSH EHRERILELS TQARMELQQL
   361  ISVWIQAQSK KTKSIAEELE LSILKISHSL NELKKELHST ATQLAADLLK YHADHVVLKA
   421  LKLTGVEGNL EALAEYACKL SEQKEQLVET CRLLRHISGT EPLEITCIHA EETFQVTGQQ
   481  IISAAETLTL HPSSKIAKEN LDVFCEAWES QISDMSTLLR EINDVFEGRR GEKYGYLSLP
   541  KPMKNNANLK SLKPDKPDSE EQAKIAKLGL KLGLLTSDAD CEIEKWEDQE NEIVQYGRNM
   601  SSMAYSLYLF TRGEGPLKTS QDLIHQLEVF AAEGLKLTSS VQAFSKQLKD DDKLMLLLEI
   661  NKLIPLCHQL QTVTKTSLQN KVFLKVDKCI TKTRSMMALL VQLLSLCYKL LKKLQMENNG
   721  WVSVTNKDTM DSKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTNNAL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
274 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 274 nTPM
  • ovary: 121 nTPM
  • thyroid gland: 79 nTPM
  • heart muscle: 71 nTPM
  • choroid plexus: 55 nTPM
  • lung: 49 nTPM

Single-cell type

  • adrenal cortex cells: 759 nCPM
  • schwann cells: 577 nCPM
  • retinal pigment epithelial cells: 439 nCPM
  • epididymal basal cells: 408 nCPM
  • esophageal apical cells: 406 nCPM
  • endometrial glandular cells: 359 nCPM

Immune cell

  • T-reg: 6.5 nTPM
  • NK-cell: 4 nTPM
  • neutrophil: 3.2 nTPM
  • MAIT T-cell: 2.1 nTPM
  • total PBMC: 1.9 nTPM
  • memory CD8 T-cell: 1.6 nTPM

Brain region

  • choroid plexus: 32 nTPM
  • cerebral cortex: 26 nTPM
  • white matter: 16 nTPM
  • hypothalamus: 15 nTPM
  • basal ganglia: 13 nTPM
  • amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
0.69
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTNNAL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTNNAL1 as an antibody target. Whether an autoantibody or antibody against CTNNAL1 could matter depends on whether native CTNNAL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTNNAL1 is annotated at the cell surface, where native CTNNAL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CTNNAL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTNNAL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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