Seroatlas · Human Serome Atlas

HSF2BP

Heat shock factor 2-binding protein

Also known as: HSF2B_HUMAN, MEILB2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75031
Gene: HSF2BP
Ensembl: ENSG00000160207
Chromosome: 21
Canonical length: 334 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>O75031|HSF2BP
     1  MGEAGAAEEA CRHMGTKEEF VKVRKKDLER LTTEVMQIRD FLPRILNGEV LESFQKLKIV
    61  EKNLERKEQE LEQLKMDCEH FKARLETVQA DNIREKKEKL ALRQQLNEAK QQLLQQAEYC
   121  TEMGAAACTL LWGVSSSEEV VKAILGGDKA LKFFSITGQT MESFVKSLDG DVQELDSDES
   181  QFVFALAGIV TNVAAIACGR EFLVNSSRVL LDTILQLLGD LKPGQCTKLK VLMLMSLYNV
   241  SINLKGLKYI SESPGFIPLL WWLLSDPDAE VCLHVLRLVQ SVVLEPEVFS KSASEFRSSL
   301  PLQRILAMSK SRNPRLQTAA QELLEDLRTL EHNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSF2BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

testis: 23 nTPM
cerebral cortex: 2.3 nTPM
midbrain: 1.2 nTPM
spinal cord: 1.2 nTPM
ovary: 1 nTPM
amygdala: 0.9 nTPM

Single-cell type

early spermatids: 107 nCPM
early primary spermatocytes: 88 nCPM
late primary spermatocytes: 48 nCPM
differentiating spermatogonia: 46 nCPM
late spermatids: 45 nCPM
undifferentiated spermatogonia: 30 nCPM

Immune cell

naive CD4 T-cell: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM
MAIT T-cell: 0.4 nTPM
NK-cell: 0.4 nTPM
memory B-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM

Brain region

cerebral cortex: 4.4 nTPM
hypothalamus: 2.8 nTPM
thalamus: 2.8 nTPM
white matter: 2.8 nTPM
pons: 2.7 nTPM
medulla oblongata: 2.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSF2BP.

Disease | AllUniProt

Conditions HSF2BP is implicated in, by any mechanism.

Premature ovarian failure 19 (POF19) MIM:619245

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 59 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Premature ovarian failure 19

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: -0.17
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
Heat shock factor 2-binding protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSF2BP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSF2BP as an antibody target. Whether an autoantibody or antibody against HSF2BP could matter depends on whether native HSF2BP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSF2BP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSF2BP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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