Seroatlas · Human Serome Atlas

FAM3C

Protein FAM3C

Also known as: FAM3C_HUMAN, GS3876, ILEI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92520
Gene: FAM3C
Ensembl: ENSG00000196937
Chromosome: 7
Canonical length: 227 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q92520|FAM3C
     1  MRVAGAAKLV VAVAVFLLTF YVISQVFEIK MDASLGNLFA RSALDTAARS TKPPRYKCGI
    61  SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV GRGINVALAN GKTGEVLDTK
   121  YFDMWGGDVA PFIEFLKAIQ DGTIVLMGTY DDGATKLNDE ARRLIADLGS TSITNLGFRD
   181  NWVFCGGKGI KTKSPFEQHI KNNKDTNKYE GWPEVVEMEG CIPQKQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 167 nTPM

Expression across tissuesHPA

Tissue

duodenum: 167 nTPM
small intestine: 149 nTPM
thyroid gland: 104 nTPM
cervix: 91 nTPM
pancreas: 70 nTPM
cerebral cortex: 69 nTPM

Single-cell type

enterocytes: 257 nCPM
parietal cells: 237 nCPM
endometrial secretory cells: 190 nCPM
endometrial glandular cells: 159 nCPM
gastric chief cells: 155 nCPM
epididymal efferent duct ciliated cells: 152 nCPM

Immune cell

memory B-cell: 23 nTPM
naive B-cell: 20 nTPM
NK-cell: 3.1 nTPM
gdT-cell: 2.1 nTPM
MAIT T-cell: 2 nTPM
memory CD8 T-cell: 1.7 nTPM

Brain region

cerebral cortex: 72 nTPM
pons: 59 nTPM
basal ganglia: 51 nTPM
white matter: 48 nTPM
hippocampal formation: 46 nTPM
hypothalamus: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.1
gnomAD missense Z: 1.15
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RMDN3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM3C as an antibody target. Whether an autoantibody or antibody against FAM3C could matter depends on whether native FAM3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM3C is annotated as secreted, so native FAM3C circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FAM3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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